ArticleAnnals of Saudi medicine
Time-to-detection of bacteria and yeast with the BACTEC FX versus BacT/Alert Virtuo blood culture systems.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of Automated Blood Culture Systems on the Management of Bloodstream Infections: Results from a Crossover Diagnostic Clinical Trial.Microbiology spectrum · 2022Trial
- Situation and questions regarding the practice of blood cultures in paediatric patients: an opinion paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Cost-Effectiveness of Automated Blood Culture Systems: Comparison of BACT/ALERT VIRTUO and BD BACTEC FX from a Provider Perspective.ClinicoEconomics and outcomes research : CEOR · 2026Article
- Duration of same-species antimicrobial non-susceptibility persistence in urinary gram-negative bacilli: a 12-year within-patient cohort study.Frontiers in cellular and infection microbiology · 2026Article
- MultiSeq-AMR: a modular amplicon-sequencing workflow for rapid detection of bloodstream infection and antimicrobial resistance markers.Microbial genomics · 2025Article
- Optimization and Testing of a Commercial Viability PCR Protocol to DetectMicroorganisms · 2024Article
- Increased growth temperature and vitamin B12 supplementation reduces the lag time for rapid pathogen identification in BHI agar and blood cultures.F1000Research · 2023Article
- Unresolved issues in the epidemiology and diagnosis of bacteremia: an opinion paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Review
- Clinical Significance of BD Bactec FX Blood Culture Incubation Beyond 96 Hours (4 Days).Journal of clinical microbiology · 2022Article
- The Impact of Implementing the Virtuo Blood Culture System on the Characteristics and Management of Patients with Staphylococcus aureus Bacteremia.Journal of clinical microbiology · 2022Article
- Bacterial Coinfection and Antibiotic Resistance Profiles among Hospitalised COVID-19 Patients.Microorganisms · 2022Article
- Considerations in evaluating equipment-free blood culture bottles: A short protocol for use in low-resource settings.PloS one · 2022Article
- Real-World Evaluation of the Impact of Implementation of the Virtuo Blood Culture System in a Tertiary Care Hospital.Journal of clinical microbiology · 2021Article
- Comparison of Microorganism Detection and Time to Positivity in Pediatric and Standard Media from Three Major Commercial Continuously Monitored Blood Culture Systems.Journal of clinical microbiology · 2021Article
- Effect of delayed entry on performance of the BACT/ALERT FAN PLUS bottles in the BACT/ALERT VIRTUO blood culture system.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Evaluation of Optimal Blood Culture Incubation Time To Maximize Clinically Relevant Results from a Contemporary Blood Culture Instrument and Media System.Journal of clinical microbiology · 2021Article
- New Microbiological Techniques for the Diagnosis of Bacterial Infections and Sepsis in ICU Including Point of Care.Current infectious disease reports · 2021Review
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Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBloodstream infections are associated with high rates of morbidity and mortality. Rapid detection of bloodstream infections is important in achieving better patient outcomes.
objectiveCompare the time-to-detection (TTD) of the new BacT/Alert Virtuo and the BACTEC FX automated blood culture systems.
designProspective simulated comparison of two instruments using seeded samples.
settingMedical microbiology laboratory.
methodsBlood culture bottles were seeded in triplicate with each of the standard ATCC strains of aerobes, anaerobes and yeast. TTD was calculated as the length of time from the beginning of culture incubation to the detection of bacterial growth.
main outcome measuresTTD for the various tested organisms on the two microbial detection systems.
resultsThe 99 bottles of seeded blood cultures incubated in each of the blood culture systems included 21 anaerobic, 39 aerobic and 39 pediatric bottles. The BacT/Alert Virtuo system exhibited significantly shorter TTD for 72.7 % of the tested organisms compared to BACTEC FX system with a median difference in mean TTD of 2.1 hours (interquartile range: 1.5-3.5 hours). The BACTEC FX system was faster in 15.2% (5/33) of microorganisms, with a median difference in mean TTD of 25.9 hours (IQR: 9.1-29.2 hours).
conclusionTTD was significantly shorter for most of the microorganisms tested on the new BacT/Alert Virtuo system compared to the BACTEC FX system. LIMITATIONS: Use of simulated cultures to assess TTD may not precisely represent clinical blood cultures. CONFLICT OF INTEREST: None.
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