Evidence map›Paper›PMID 29848786›Full record

ArticleNeurology2018

Relating structural and functional brainstem connectivity to disease measures in epilepsy.

Dario J Englot, Hernan F J Gonzalez, Bryson B Reynolds, Peter E Konrad, Monica L Jacobs, John C Gore, Bennett A Landman, Victoria L Morgan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The clinical and predictive value ofCNS neuroscience & therapeutics · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Dario J EnglotFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN. englot@gmail.com.
Hernan F J GonzalezFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Bryson B ReynoldsFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Peter E KonradFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Monica L JacobsFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
John C GoreFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Bennett A LandmanFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Victoria L MorganFrom the Departments of Neurological Surgery (D.J.E., P.E.K.), Biomedical Engineering (D.J.E., H.F.J.G., P.E.K., B.A.L., V.L.M.), Radiology and Radiological Sciences (D.J.E., B.B.R., J.C.G., B.A.L., V.L.M.), Psychiatry and Behavioral Sciences (M.L.J.), and the Vanderbilt University Institute of Imaging Science (D.J.E., H.F.J.G., B.B.R., J.C.G., B.A.L., V.L.M.), Vanderbilt University Medical Center, Nashville, TN.
Research Institute of Radiology · BY

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Training Program for Innovative Engineering Research in Surgery and InterventionT32EB021937 · NIBIB · VANDERBILT UNIVERSITY · PI Dario J Englot, Michael Ian Miga · 2016 to 2026
$2.3M
MRI Structural and Functional Connectivity Changes in Temporal Lobe EpilepsyR01NS075270 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MORGAN, VICTORIA L · 2012 to 2016
$1.7M
MULTIMODAL MAPPING OF SUBCORTICAL AND CORTICAL FUNCTIONAL NETWORK DISTURBANCES IN FOCAL EPILEPSYR00NS097618 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2017 to 2019
$743k
MULTIMODAL MAPPING OF SUBCORTICAL AND CORTICAL FUNCTIONAL NETWORK DISTURBANCES IN FOCAL EPILEPSYK99NS097618 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGLOT, DARIO J · 2016 to 2016
$83k
NIBIB NIH HHS T32 EB001628NIBIB NIH HHS T32 EB021937NICHD NIH HHS U54 HD083211NIGMS NIH HHS T32 GM007347NINDS NIH HHS K99 NS097618NINDS NIH HHS R00 NS097618NINDS NIH HHS R01 NS075270
6 · The paper itself

Abstract

objectiveWhile epilepsy studies rarely examine brainstem, we sought to examine the hypothesis that temporal lobe epilepsy (TLE) leads to subcortical arousal center dysfunction, contributing to neocortical connectivity and neurocognitive disturbances.

methodsIn this case-control study of 26 adult patients with TLE and 26 controls, we used MRI to measure structural and functional connectivity of the cuneiform/subcuneiform nuclei (CSC), pedunculopontine nucleus, and ventral tegmental area. Ascending reticular activating system connectivity patterns were related to neuropsychological and disease measures.

resultsCompared to controls, patients with TLE demonstrated reductions in ascending reticular activating system structural and functional connectivity, most prominently to neocortical regions (

conclusionsConnectivity perturbations in brainstem arousal centers are present in TLE and may contribute to neurocognitive problems. These studies demonstrate the underappreciated role of brainstem networks in epilepsy and may lead to novel neuromodulation targets to treat or prevent deleterious brain network effects of seizures in TLE.

Indexed as

AdultBrain StemCase-Control StudiesCognition DisordersEpilepsyFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsOxygenRetrospective StudiesOxygen

Identifiers

PMID29848786
PMCPMC6091881
OpenAlexW2807283120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.