Evidence map›Paper›PMID 29848781›Full record

ArticleMolecular & cellular proteomics : MCP2018

Discovery of Novel Cell Surface Markers for Purification of Embryonic Dopamine Progenitors for Transplantation in Parkinson's Disease Animal Models.

Ali Fathi, Mehdi Mirzaei, Banafsheh Dolatyar, Mehdi Sharifitabar, Mahnaz Bayat, Ebrahim Shahbazi, Jaesuk Lee, Mohammad Javan, Su-Chun Zhang, Vivek Gupta and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Proteomic Exploration of L1CAMInternational journal of molecular sciences · 2025
    Article
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  16. The quest of cell surface markers for stem cell therapy.Cellular and molecular life sciences : CMLS · 2021
    Review
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  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 5 countries.

Ali FathiFrom the ‡Department of Molecular Systems Biology.
Mehdi Mirzaei‡‡Department of Molecular Sciences.
Banafsheh Dolatyar¶Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
Mehdi SharifitabarFrom the ‡Department of Molecular Systems Biology.
Mahnaz Bayat‖‖Center for Regenerative Medicine, Gachon University Medical School, Incheon, Korea.
Ebrahim ShahbaziFrom the ‡Department of Molecular Systems Biology.
Jaesuk Lee‖‖Center for Regenerative Medicine, Gachon University Medical School, Incheon, Korea.
Mohammad Javan§Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Su-Chun Zhang‖Waisman Center.
Vivek Gupta¶¶Department of Clinical Medicine, Macquarie University, Sydney, NSW, Australia.
Bonghee Lee‖‖Center for Regenerative Medicine, Gachon University Medical School, Incheon, Korea.
Paul A Haynes‡‡Department of Molecular Sciences.
Hossein Baharvand¶Department of Developmental Biology, University of Science and Culture, Tehran, Iran; salekdeh@Royaninstitute.org Baharvand@Royaninstitute.org.
Ghasem Hosseini SalekdehFrom the ‡Department of Molecular Systems Biology, salekdeh@Royaninstitute.org Baharvand@Royaninstitute.org.ORCID 0000-0002-5124-4721
University of Science and Culture · IRGachon University · KRAGRF Ltd · AUInstitute of Molecular Biology of the Slovak Academy of Sciences · SKMacquarie University · AUMolecular Sciences Institute · USRoyan Institute · IRTarbiat Modares University · IRUniversity of Wisconsin System · US

Funding

Individualized Cell Therapy for Parkinson's DiseaseR01NS076352 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ZHANG, SU-CHUN · 2012 to 2016
$3.1M
Reconstruction and Regulation of Neural Circuitry by Human NeuronsR01NS096282 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ZHANG, SU-CHUN · 2017 to 2021
$1.7M
NINDS NIH HHS R01 NS076352NINDS NIH HHS R01 NS096282
6 · The paper itself

Abstract

Despite the progress in safety and efficacy of cell replacement therapy with pluripotent stem cells (PSCs), the presence of residual undifferentiated stem cells or proliferating neural progenitor cells with rostral identity remains a major challenge. Here we report the generation of a LIM homeobox transcription factor 1 alpha (LMX1A) knock-in GFP reporter human embryonic stem cell (hESC) line that marks the early dopaminergic progenitors during neural differentiation to find reliable membrane protein markers for isolation of midbrain dopaminergic neurons. Purified GFP positive cells

Indexed as

AnimalsBiomarkersCell DifferentiationCell MembraneCell SeparationContactin 2Disease Models, AnimalDopaminergic NeuronsEmbryonic Stem CellsFemaleGreen Fluorescent ProteinsHumansLIM-Homeodomain ProteinsParkinson DiseaseProteomicsRats, Sprague-DawleyBiomarkersContactin 2Green Fluorescent ProteinsLIM-Homeodomain ProteinsLMX1A protein, humanTranscription Factors

Identifiers

PMID29848781
PMCPMC6126395
OpenAlexW2805455222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.