Evidence map›Paper›PMID 29848771›Full record

ArticleBMJ open2018

Early detection of congenital anomalies of the kidney and urinary tract: cross-sectional results of a community-based screening and referral study in China.

Yinv Gong, Ying Zhang, Qian Shen, Liping Xiao, Yihui Zhai, Yunli Bi, Jian Shen, Hong Chen, Yun Li, Hong Xu

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06018831 (Urine and Ultrasound Screening for Kidney Disease in Children), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06018831 narecruitingnot on this mapstarted 2022, after this paper: background citation

Urine and Ultrasound Screening for Kidney Disease in Children

TypeinterventionalSponsorChildren's Hospital of Fudan UniversityRan2022 to 2028Enrolled13,000ConditionsKidney Diseases, Diagnostic Techniques, Ultrasound, UrinalysisArmsUrine and Ultrasound Screening
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yinv GongDepartment of Nephrology, Children's Hospital of Fudan University, Shanghai, China.
Ying ZhangDepartment of Child Health, Minhang Maternal and Child Health Hospital, Shanghai, China.
Qian ShenDepartment of Nephrology, Children's Hospital of Fudan University, Shanghai, China.
Liping XiaoDepartment of Child Health, Minhang Maternal and Child Health Hospital, Shanghai, China.
Yihui ZhaiDepartment of Nephrology, Children's Hospital of Fudan University, Shanghai, China.
Yunli BiDepartment of Urology, Children's Hospital of Fudan University, Shanghai, China.
Jian ShenDepartment of Urology, Children's Hospital of Fudan University, Shanghai, China.
Hong ChenDepartment of Urology, Children's Hospital of Fudan University, Shanghai, China.
Yun LiDepartment of Child Health, Minhang Maternal and Child Health Hospital, Shanghai, China.
Hong XuDepartment of Nephrology, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo establish an effective screening model of congenital anomalies of the kidney and urinary tract (CAKUT) using ultrasound among neonates in Shanghai, China.

designCross-sectional study.

settingA three-level screening model for CAKUT in neonates based on the child healthcare system was established since 2010 in Minhang District, Shanghai, China.

participantsDuring 2010-2015, neonates with criteria such as preterm, low birth weight and so on were eligible to participate in the study. Cases with renal pelvis dilatation (RPD) and other abnormal renal findings were managed based on presumed strategies.

main outcome measuresThe proportion of RPD and other renal and urinary tract anomalies; number of diagnosed CAKUT under integrated management, especially obstructive uropathy. The anterior-posterior renal pelvic diameter (APRPD) cut-off points for likelihood of obstructive uropathy and need for surgery.

resultsA total of 8827 infants were consecutively screened. Absolute and relative rates of different degrees of RPD classified by APRPD were: mild (5-9.9 mm), 984 (11.1%); moderate (10-14.9 mm), 176 (2.0%); severe (≥15 mm), 20 (0.2%). Of 639 followed cases with RPD, 11 were diagnosed as obstructive uropathies. Of these, nine patients underwent surgery, at median age 2 months. A total 85.4% of mild, 62.5% of moderate and 30.0% of severe RPD cases resolved spontaneously. Other renal and urinary morphological abnormalities were diagnosed in 15 (0.2%) patients. The APRPD cut-off points for significant obstructive uropathy and need for surgery were 9.7 mm and 13.5 mm, respectively.

conclusionsThis three-level screening model is an effective and feasible strategy for early detection and intervention of CAKUT in the early postnatal period, especially for patients with high-grade RPD and other renal and urinary malformations. This strategy could be useful in China and other developing areas with limited medical resources.

Indexed as

Early DiagnosisChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornKaplan-Meier EstimateMaleMass ScreeningReferral and ConsultationROC CurveSeverity of Illness IndexUltrasonographyUrogenital AbnormalitiesVesico-Ureteral Refluxcongenital anomalies of the kidney and urinary tract (CAKUT)neonatethree-level networkultrasound screening

Identifiers

PMID29848771
PMCPMC5988092
OpenAlexW2805245328

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.