Evidence map›Paper›PMID 29848658›Full record

ArticleJournal of cell science2018

A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.

Katherine H Fisher, Maria Fragiadaki, Dhamayanthi Pugazhendhi, Nina Bausek, Maria A Arredondo, Sally J Thomas, Stephen Brown, Martin P Zeidler

Abstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Identification ofPathogens (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katherine H FisherThe Bateson Centre, Department of Biomedical Science, The University of Sheffield, Firth Court, Sheffield, S10 2TN, UK.ORCID 0000-0002-2751-156X
Maria FragiadakiThe Bateson Centre, Department of Biomedical Science, The University of Sheffield, Firth Court, Sheffield, S10 2TN, UK.ORCID 0000-0002-1587-5577
Dhamayanthi PugazhendhiThe Bateson Centre, Department of Biomedical Science, The University of Sheffield, Firth Court, Sheffield, S10 2TN, UK.ORCID 0000-0003-0270-6552
Nina BausekThe Bateson Centre, Department of Biomedical Science, The University of Sheffield, Firth Court, Sheffield, S10 2TN, UK.ORCID 0000-0003-2415-1463
Maria A ArredondoDepartment of Oncology & Human Metabolism, The University of Sheffield, Sheffield, S10 2RX, UK.
Sally J ThomasDepartment of Oncology & Human Metabolism, The University of Sheffield, Sheffield, S10 2RX, UK.
Stephen BrownThe Sheffield RNAi Screening Facility, Department of Biomedical Science, The University of Sheffield, S10 2TN, UK.
Martin P ZeidlerThe Bateson Centre, Department of Biomedical Science, The University of Sheffield, Firth Court, Sheffield, S10 2TN, UK m.zeidler@sheffield.ac.uk.ORCID 0000-0003-2942-1135

Funding

Cancer Research UK C24089/A8301Medical Research Council G120/870Wellcome TrustWellcome Trust 084757
6 · The paper itself

Abstract

Cytokine receptors often act via the Janus kinase and signal transducer and activator of transcription (JAK/STAT) pathway to form a signalling cascade that is essential for processes such as haematopoiesis, immune responses and tissue homeostasis. In order to transduce ligand activation, cytokine receptors must dimerise. However, mechanisms regulating their dimerisation are poorly understood. In order to better understand the processes regulating cytokine receptor levels, and their activity and dimerisation, we analysed the highly conserved JAK/STAT pathway in

Indexed as

Genome, InsectRNA InterferenceAmino Acid MotifsAnimalsDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsGene Expression RegulationHumansJanus KinasesProtein BindingProtein StabilityReceptors, CytokineReceptors, InterleukinRNA-Binding ProteinsSignal TransductionANKHD1 protein, humanDNA-Binding Proteinsdome protein, DrosophilaDrosophila ProteinsJanus KinasesMask protein, DrosophilaReceptors, CytokineReceptors, InterleukinRNA-Binding ProteinsSTAT Transcription FactorsANKYRIN domainCytokine receptorDimerisationJAK/STATRNAi

Identifiers

PMID29848658
PMCPMC6051347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.