ArticleJournal of clinical microbiology2018
Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 2 pooled it
12.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- Pooled it
- Metagenomic Sequencing as a Pathogen-Agnostic Clinical Diagnostic Tool for Infectious Diseases: a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies.Journal of clinical microbiology · 2021Pooled it
- Algorithmic Determinants of Performance Heterogeneity in Whole-Genome Sequencing-Based Prediction of Drug Resistance inMicroorganisms · 2026Review
- What is new in tuberculosis?Clinical medicine (London, England) · 2026Review
- Optimizing culture-free approaches to recover high-qualityMicrobial genomics · 2026Article
- Current Landscape of Molecular Diagnostic Tests and Emerging Tools for Tuberculosis and Drug Resistance.Diagnostics (Basel, Switzerland) · 2026Review
- Pilot evaluation of a compact targeted next-generation sequencing with minimum biocontainment for rapid diagnosis of drug-resistant tuberculosis.Microbiology spectrum · 2026Article
- Evaluation of DNA extraction methods from clinical Mycobacterium tuberculosis primary liquid culture for whole-genome sequencing.BMC genomics · 2026Article
- Direct nanopore sequencing ofMicrobial genomics · 2026Article
- Comparison of culture and culture-free methods for comprehensive identification of mycobacteria: a single-center prospective study.Journal of clinical microbiology · 2026Article
- Genetic diversity and drug resistance profiles ofMicrobiology spectrum · 2026Article
- Rapid Identification of Drug-Resistant Tuberculosis Using Nanopore Targeted Next-Generation Sequencing from Sputum and Culture Isolates: Accuracy and Limitations.Infection and drug resistance · 2026Article
- Optimizing culture-free approaches to recover high qualitymedRxiv : the preprint server for health sciences · 2025Article
- Detection, Isolation, and Identification of Mycobacteria That Cause Nontuberculous Mycobacterial Disease and Tuberculosis.Pathogens (Basel, Switzerland) · 2025Review
- Targeted next-generation sequencing for drug-resistant tuberculosis diagnosis: implementation considerations for bacterial load, regimen selection and diagnostic algorithm placement.BMJ global health · 2025Observational
- Ecology, global diversity and evolutionary mechanisms in the Mycobacterium tuberculosis complex.Nature reviews. Microbiology · 2025Review
- Mycobacterial DNA Extraction using Bead Beating in Custom Buffer Followed by NGS Workflow.Journal of visualized experiments : JoVE · 2025Article
- Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.Genomics, proteomics & bioinformatics · 2025Article
- A pragmatic pipeline for drug resistance and lineage identification in Mycobacterium tuberculosis using whole genome sequencing.PLOS global public health · 2025Article
- Advancing the fight against tuberculosis: integrating innovation and public health in diagnosis, treatment, vaccine development, and implementation science.Frontiers in medicine · 2025Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 1 country.
Ronan M DoyleDivision of Infection and Immunity, University College London, London, United Kingdom ronan.doyle@gosh.nhs.uk.ORCID 0000-0001-5001-1945
Carrie BurgessDivision of Infection and Immunity, University College London, London, United Kingdom.
Rachel WilliamsDivision of Infection and Immunity, University College London, London, United Kingdom.
Rebecca GortonCentre for Clinical Microbiology, Division of Infection and Immunity, Royal Free Campus, UCL, London, United Kingdom.
Helen BoothUniversity College London Hospitals NHS Foundation Trust, London, United Kingdom.
James BrownRoyal Free London NHS Foundation Trust, London, United Kingdom.
Josephine M BryantMolecular Immunity Unit, MRC Laboratory of Molecular Biology, Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Jackie ChanOxford Gene Technology, Oxford Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom.
Dean CreerRoyal Free London NHS Foundation Trust, London, United Kingdom.
Jolyon HoldstockOxford Gene Technology, Oxford Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom.
Heinke KunstBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Stefan LozewiczNorth Middlesex University Hospital NHS Trust, London, United Kingdom.
Gareth PlattCentre for Clinical Microbiology, Division of Infection and Immunity, Royal Free Campus, UCL, London, United Kingdom.
Erika Yara RomeroDivision of Infection and Immunity, University College London, London, United Kingdom.
Graham SpeightOxford Gene Technology, Oxford Begbroke Science Park, Begbroke, Oxfordshire, United Kingdom.
Simon TiberiBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Ibrahim AbubakarUCL Institute for Global Health, University College London, London, United Kingdom.
Marc LipmanRoyal Free London NHS Foundation Trust, London, United Kingdom.
Timothy D McHughCentre for Clinical Microbiology, Division of Infection and Immunity, Royal Free Campus, UCL, London, United Kingdom.
Judith BreuerDivision of Infection and Immunity, University College London, London, United Kingdom.
University College London · GBOxford Gene Technology (United Kingdom) · GBRoyal Free London NHS Foundation Trust · GBThe Royal Free Hospital · GBQueen Mary University of London · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBMRC Laboratory of Molecular Biology · GBNorth Middlesex University Hospital NHS Trust · GBUniversity College London Hospitals NHS Foundation Trust · GB
Funding
Medical Research Council G0900950
Abstract
The current methods available to diagnose antimicrobial-resistant
Indexed as
Whole Genome SequencingAntitubercular AgentsDrug Resistance, BacterialEarly DiagnosisGenome, BacterialHumansMicrobial Sensitivity TestsMolecular Diagnostic TechniquesMycobacterium tuberculosisSputumTuberculosisTuberculosis, Multidrug-ResistantAntitubercular Agentsantimicrobial resistanceMycobacterium tuberculosispathogen DNA enrichmentwhole-genome sequencing
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.