Evidence map›Paper›PMID 29848551›Full record

ArticleThe Journal of biological chemistry2018

The architecture of the OmpC-MlaA complex sheds light on the maintenance of outer membrane lipid asymmetry in

Jiang Yeow, Kang Wei Tan, Daniel A Holdbrook, Zhi-Soon Chong, Jan K Marzinek, Peter J Bond, Shu-Sin Chng

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Following phospholipid transfer through the OmpFProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Elucidating Antibiotic Permeation through theJournal of chemical information and modeling · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A periplasmic phospholipase that maintains outer membrane lipid asymmetry inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. ABC Transporters in Bacterial Nanomachineries.International journal of molecular sciences · 2023
    Review
  17. Lipid Transport Across Bacterial Membranes.Annual review of cell and developmental biology · 2022
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiang YeowDepartment of Chemistry, National University of Singapore, Singapore 117543; National University of Singapore Graduate School for Integrative Sciences and Engineering, Singapore 117456.
Kang Wei TanDepartment of Chemistry, National University of Singapore, Singapore 117543.
Daniel A HoldbrookBioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore 138671.
Zhi-Soon ChongDepartment of Chemistry, National University of Singapore, Singapore 117543.
Jan K MarzinekBioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore 138671; Department of Biological Sciences, National University of Singapore, Singapore 117543.
Peter J BondBioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore 138671; Department of Biological Sciences, National University of Singapore, Singapore 117543. Electronic address: peterjb@bii.a-star.edu.sg.
Shu-Sin ChngDepartment of Chemistry, National University of Singapore, Singapore 117543; Singapore Center for Environmental Life Sciences Engineering, National University of Singapore, Singapore 117456. Electronic address: chmchngs@nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A distinctive feature of the Gram-negative bacterial cell envelope is the asymmetric outer membrane (OM), where lipopolysaccharides and phospholipids (PLs) reside in the outer and inner leaflets, respectively. This unique lipid asymmetry renders the OM impermeable to external insults, including antibiotics and bile salts. In

Indexed as

Biological TransportEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsHumansLipid BilayersModels, MolecularPhospholipidsPhospholipid Transfer ProteinsPorinsProtein Interaction MapsProtein MultimerizationEscherichia coli ProteinsLipid BilayersMlaA protein, E coliOmpC proteinPhospholipidsPhospholipid Transfer ProteinsPorinslipid asymmetrylipid transportmembrane channelmembrane proteinMlaAOmpCosmoporinouter membranephospholipidprotein complex

Identifiers

PMID29848551
PMCPMC6065193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.