ArticleBMJ (Clinical research ed.)2018
Long term survival, health, social functioning, and education in patients with European Lyme neuroborreliosis: nationwide population based cohort study.
Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Long-Term Sequelae and Health-Related Quality of Life Associated With Lyme Disease: A Systematic Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Lyme borreliosis.Nature reviews. Disease primers · 2026Review
- The diagnostic potential of proteomics and machine learning in Lyme neuroborreliosis.Nature communications · 2025Article
- Seroprevalence of tick-borne infections in blood donors in Europe: a systematic review.New microbes and new infections · 2025Review
- Residual Symptoms and Quality of Life After Treated Lyme Neuroborreliosis: Case-Control Study (QoLYME).Open forum infectious diseases · 2025Article
- Sensorineural hearing loss in Lyme neuroborreliosis.Annals of medicine · 2024Article
- Confounding and Negative Control Methods in Observational Study of SARS-CoV-2 Vaccine Effectiveness: A Nationwide, Population-Based Danish Health Registry Study.Clinical epidemiology · 2024Article
- Fatigue and cognitive impairment in neuroborreliosis patients posttreatment-A neuropsychological retrospective cohort study.Brain and behavior · 2022Article
- Cognitive function in patients with neuroborreliosis: A prospective cohort study from the acute phase to 12 months post treatment.Brain and behavior · 2022Article
- Burden of Tick-Borne Encephalitis, Sweden.Emerging infectious diseases · 2022Article
- Neurofilament Light in Cerebrospinal Fluid is Associated With Disease Staging in European Lyme Neuroborreliosis.Journal of central nervous system disease · 2022Article
- Persistent Anti-Microbiology spectrum · 2021Article
- Existing Data Sources for Clinical Epidemiology: The Danish Study Group of Infections of the Brain Database (DASGIB).Clinical epidemiology · 2021Review
- Article
- Patient-reported outcome after treatment for definite Lyme neuroborreliosis.Brain and behavior · 2020Article
- Long-Term Survival, Morbidity, Social Functioning and Risk of Disability in Patients with a Herpes Simplex Virus Type 1 or Type 2 Central Nervous System Infection, Denmark, 2000-2016.Clinical epidemiology · 2020Article
- Infectious causes of peripheral facial nerve palsy in children-a retrospective cohort study with long-term follow-up.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Lyme neuroborreliosis epidemiology in Sweden 2010 to 2014: clinical microbiology laboratories are a better data source than the hospital discharge diagnosis register.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Observational
- The Emerging Role of Microbial Biofilm in Lyme Neuroborreliosis.Frontiers in neurology · 2018Review
- Disseminated Marginal Zone Lymphoma in a Patient with Lyme Neuroborreliosis: A Case Report.Case reports in oncologyArticle
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Authors and funding
17 authors at 11 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo estimate long term survival, health, and educational/social functioning in patients with Lyme neuroborreliosis compared with the general population.
designNationwide population based cohort study using national registers.
settingDenmark.
participantsAll Danish residents diagnosed during 1986-2016 as having Lyme neuroborreliosis (n=2067), defined as a positive
main outcome measuresMortality rate ratios, incidence rate ratios of comorbidities, and differences in educational and social outcomes.
resultsMortality among patients with Lyme neuroborreliosis was not higher than in the general population (mortality rate ratio 0.90, 95% confidence interval 0.79 to 1.03). Lyme neuroborreliosis patients had increased risk of haematological (incidence rate ratio 3.07, 2.03 to 4.66) and non-melanoma skin cancers (1.49, 1.18 to 1.88). At diagnosis, Lyme neuroborreliosis patients had slightly higher employment and lower disability pension rates. After five years, patients and comparison cohort members had similar numbers of hospital contacts (difference -0.22, 95% confidence interval -0.45 to 0.02, in-hospital days/year; 0.37, -0.10 to 0.83, outpatient visits/year), employment rates (difference 1.5%, -2.1% to 5.1%), income (difference -1000, -20 000 to 18 000, Danish kroner), days of sick leave (difference -0.3, -3.5 to 3.0, per year), rates of receipt of a disability pension (difference -0.9%, -3.2% to 1.3%), and number of children (difference -0.10, -0.27 to 0.08). More patients were married (difference 4.8%, 2.2% to 7.4%) and had completed high school education (difference 7%, 1% to 12%).
conclusionA verified diagnosis of Lyme neuroborreliosis had no substantial effect on long term survival, health, or educational/social functioning. Nevertheless, the diagnosis decreased labour market involvement marginally and was associated with increased risk of haematological and non-melanoma skin cancers.
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