Evidence map›Paper›PMID 29848525›Full record

ArticleBMJ case reports2018

Left ventricular mural thrombus despite treatment with dabigatran and clopidogrel.

Maise Fredgart, Sabine Gill

Open access · greenAbstract readCase ReportsVideo-Audio Media
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maise FredgartDepartment of Cardiology, Odense Universitetshospital, Odense, Denmark.ORCID http://orcid.org/0000-0001-9609-2664
Sabine GillDepartment of Cardiology, Odense Universitetshospital, Odense, Denmark.
Odense University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a case with severe heart failure and moderate aortic stenosis. Due to previous atrial fibrillation and ischaemic heart disease, this patient was treated with both dabigatran and clopidogrel. Despite this, a large mural thrombus was found on echocardiography. The treatment was altered to warfarin, but the thrombus did not resolve during the next eight months.Guidelines for the use of anticoagulant treatment in left ventricular thrombus are needed. Previously, a few cases presenting resistance to novel oral anticoagulants have been published and cases with thrombus formation due to dabigatran have been described. Our patient showed resistance to both dabigatran and warfarin, and there was no thrombus resolution when changing the treatment to warfarin.

Indexed as

Aged, 80 and overAnticoagulantsAntithrombinsAtrial FibrillationClopidogrelDabigatranDiagnosis, DifferentialDrug Therapy, CombinationDyspneaEchocardiographyFatal OutcomeHeart DiseasesHeart FailureHumansMaleThrombosisAnticoagulantsAntithrombinsClopidogrelDabigatranTiclopidineWarfarincardiovascular systemheart failureischaemic heart disease

Identifiers

PMID29848525
PMCPMC5990090
OpenAlexW2805073932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.