Evidence map›Paper›PMID 29848507›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway.

Silvana Bazúa-Valenti, Lorena Rojas-Vega, María Castañeda-Bueno, Jonatan Barrera-Chimal, Rocío Bautista, Luz G Cervantes-Pérez, Norma Vázquez, Consuelo Plata, Adrián R Murillo-de-Ozores, Lorenza González-Mariscal and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Hypercalcemia's Hidden Regulator: Calcium-Sensing Receptor and the Kidney's Secret Weapon.Journal of the American Society of Nephrology : JASN · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. The role ofJournal of pharmaceutical analysis · 2023
    Review
  10. Thirty years of the NaCl cotransporter: from cloning to physiology and structure.American journal of physiology. Renal physiology · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. WNK4 kinase: from structure to physiology.American journal of physiology. Renal physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Silvana Bazúa-ValentiMolecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID 0000-0001-8907-3852
Lorena Rojas-VegaDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
María Castañeda-BuenoDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Jonatan Barrera-ChimalMolecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Rocío BautistaDepartments of Molecular Biology and.
Luz G Cervantes-PérezPharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Norma VázquezMolecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Consuelo PlataDepartment of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Adrián R Murillo-de-OzoresMolecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Lorenza González-MariscalDepartment of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City, Mexico.
David H EllisonDepartment of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-2915-265X
Daniela RiccardiSchool of Biosciences, Cardiff University, Cardiff, United Kingdom; and.ORCID 0000-0002-7322-3163
Norma A BobadillaMolecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.ORCID 0000-0002-3153-9151
Gerardo GambaMolecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico; gamba@biomedicas.unam.mx.ORCID 0000-0002-4378-9043
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXUniversidad Nacional Autónoma de México · MXCardiff University · GBCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXInstituto Nacional de Cardiología · MXOregon Health & Science University · US

Funding

WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4M
NIDDK NIH HHS R01 DK051496
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCarrier ProteinsEnzyme ActivationHEK293 CellsHumansImidazolesMaleMiceMicrofilament ProteinsOocytesPhenethylaminesPhosphorylationPropylaminesProtein Kinase CProtein Kinase InhibitorsAdaptor Proteins, Signal TransducingCarrier ProteinsCASR protein, humanCASR protein, mouseImidazolesKLHL3 protein, humanMicrofilament ProteinsN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylaminePhenethylaminesPrkwnk4 protein, mousePropylaminesProtein Kinase CProtein Kinase InhibitorsProtein Serine-Threonine KinasesPyrrolidinesReceptors, Calcium-SensingReceptors, G-Protein-CoupledSlc12a1 protein, mouseSLC12A3 protein, humanSlc12a3 protein, mouseSodiumSolute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3STK39 protein, humanStk39 protein, mouseWNK463WNK4 protein, humanXenopus Proteinsdistal tubulediureticshypertensionNa transport

Identifiers

PMID29848507
PMCPMC6050918
OpenAlexW2805134926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.