Evidence map›Paper›PMID 29848501›Full record

ArticleDevelopment (Cambridge, England)2018

Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in

Jemma L Webber, Jie Zhang, Alex Massey, Nicelio Sanchez-Luege, Ilaria Rebay

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  13. Outstanding questions in developmental ERK signaling.Development (Cambridge, England) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jemma L WebberBen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.
Jie ZhangBen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.
Alex MasseyBen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0283-1142
Nicelio Sanchez-LuegeBen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA.
Ilaria RebayBen May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA irebay@uchicago.edu.ORCID 0000-0002-2444-3864

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Cell-Cell Signaling In Embryonic and Retinal Development-Revised RenewalR01EY012549 · NEI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Ilaria Rebay · 1999 to 2026
$7.3M
Function and Regulation of the ETS Transcriptional Repressor Tel-1/YANR01GM080372 · NIGMS · UNIVERSITY OF CHICAGO · PI REBAY, ILARIA · 2007 to 2022
$3.9M
NCI NIH HHS P30 CA014599NEI NIH HHS R01 EY012549NIGMS NIH HHS R01 GM080372NIGMS NIH HHS T32 GM007281NIH HHS P40 OD018537
6 · The paper itself

Abstract

The acquisition of cellular identity during development depends on precise spatiotemporal regulation of gene expression, with combinatorial interactions between transcription factors, accessory proteins and the basal transcription machinery together translating complex signaling inputs into appropriate gene expression outputs. The opposing repressive and activating inputs of the

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsEye ProteinsGene Expression RegulationNerve Tissue ProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-etsRepressor ProteinsTranscription FactorsAOP protein, DrosophilaBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsDrosophila ProteinsEye Proteinsgro protein, DrosophilaNerve Tissue Proteinspnt protein, DrosophilaProto-Oncogene ProteinsProto-Oncogene Proteins c-etsRepressor ProteinsTranscription FactorsCell fate specificationChromatin occupancyGene regulatory networkMesoderm developmentRNA pol II pausing

Identifiers

PMID29848501
PMCPMC6053666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.