Evidence map›Paper›PMID 29848500›Full record

ArticleJournal of the American Heart Association2018

In Vivo Molecular Characterization of Abdominal Aortic Aneurysms Using Fibrin-Specific Magnetic Resonance Imaging.

René M Botnar, Julia Brangsch, Carolin Reimann, Christian H P Janssen, Reza Razavi, Bernd Hamm, Marcus R Makowski

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

René M BotnarDivision of Imaging Sciences, King's College London, London, United Kingdom.
Julia BrangschDepartment of Radiology, Charite, Berlin, Germany.
Carolin ReimannDepartment of Radiology, Charite, Berlin, Germany.
Christian H P JanssenDivision of Imaging Sciences, King's College London, London, United Kingdom.
Reza RazaviDivision of Imaging Sciences, King's College London, London, United Kingdom.
Bernd HammDepartment of Radiology, Charite, Berlin, Germany.
Marcus R MakowskiDivision of Imaging Sciences, King's College London, London, United Kingdom marcus.makowski@charite.de marcus.makowski@kcl.ac.uk.
Charité - Universitätsmedizin Berlin · DEKing's College London · GBWellcome EPSRC Centre for Medical Engineering · GBWellcome Trust · GB

Funding

British Heart Foundation PG/09/061
6 · The paper itself

Abstract

backgroundThe incidence of abdominal aortic aneurysms (AAAs) will significantly increase during the next decade. Novel biomarkers, besides diameter, are needed for a better characterization of aneurysms and the estimation of the risk of rupture. Fibrin is a key protein in the formation of focal hematoma associated with the dissection of the aortic wall and the development of larger thrombi during the progression of AAAs. This study evaluated the potential of a fibrin-specific magnetic resonance (MR) probe for the in vivo characterization of the different stages of AAAs. METHODS AND

resultsAAAs spontaneously developed in ApoE

conclusionsThe fibrin-specific molecular MR probe allowed the delineation and quantification of changes in fibrin content in early and advanced AAAs. Fibrin MRI could provide a novel in vivo biomarker to improve the risk stratification of patients with aortic aneurysms.

Indexed as

Magnetic Resonance ImagingAngiotensin IIAnimalsAorta, AbdominalAortic Aneurysm, AbdominalDisease Models, AnimalFibrinMaleMice, Inbred C57BLMice, Knockout, ApoEMolecular ImagingPredictive Value of TestsAngiotensin IIFibrinabdominal aortic aneurysmfibrinimagingmagnetic resonance imaging

Identifiers

PMID29848500
PMCPMC6015382
OpenAlexW2806795057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.