Evidence map›Paper›PMID 29848375›Full record

ArticleJournal for immunotherapy of cancer2018

An update on the Society for Immunotherapy of Cancer consensus statement on tumor immunotherapy for the treatment of cutaneous melanoma: version 2.0.

Ryan J Sullivan, Michael B Atkins, John M Kirkwood, Sanjiv S Agarwala, Joseph I Clark, Marc S Ernstoff, Leslie Fecher, Thomas F Gajewski, Brian Gastman, David H Lawson and 18 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Journal for immunotherapy of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Melanoma resists chemotherapy through an adaptive mitochondrial response.Journal of experimental & clinical cancer research : CR · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Review
  14. Current Status in Rechallenge of Immunotherapy.International journal of biological sciences · 2023
    Review
  15. Wild-type IDH1 inhibition enhances chemotherapy response in melanoma.Journal of experimental & clinical cancer research : CR · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 3 countries.

Ryan J SullivanMassachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Michael B AtkinsGeorgetown University, Washington, DC, 20057, USA.
John M KirkwoodUniversity of Pittsburgh, Pittsburgh, PA, 15213, USA.
Sanjiv S AgarwalaSt. Luke's Cancer Center and Temple University, Center Valley, PA, 18034, USA.
Joseph I ClarkLoyola University Medical Center, Maywood, IL, 60153, USA.
Marc S ErnstoffRoswell Park Cancer Institute, Buffalo, NY, 14263, USA.
Leslie FecherUniversity of Michigan, Ann Arbor, MI, 48109, USA.
Thomas F GajewskiUniversity of Chicago Medical Center, Chicago, IL, 60637, USA.
Brian GastmanCleveland Clinic, Cleveland, OH, 44195, USA.
David H LawsonEmory Winship Cancer Institute, Atlanta, GA, 30322, USA.
Jose LutzkyMt. Sinai Medical Center, Miami Beach, FL, 33140, USA.
David F McDermottBeth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Kim A MargolinCity of Hope, Duarte, CA, 91010, USA.
Janice M MehnertRutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08901, USA.
Anna C PavlickNew York University Cancer Institute, New York, NY, 10016, USA.
Jon M RichardsLutheran General Hospital, Park Ridge, IL, 60068, USA.
Krista M RubinMassachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
William SharfmanThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, 21231, USA.
Steven SilversteinMelanoma Research Foundation, Woodcliff Lake, NJ, 07077, USA.
Craig L SlingluffUniversity of Virginia, Charlottesville, VA, 22908, USA.
Vernon K SondakH. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA.
Ahmad A TarhiniCleveland Clinic Taussig Cancer Center, Cleveland, OH, 44195, USA.
John A ThompsonSeattle Cancer Care Alliance, Seattle, WA, 98109, USA.
Walter J UrbaEarle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, 97213, USA.
Richard L WhiteCarolinas Medical Center, Charlotte, NC, 28204, USA.
Eric D WhitmanCarol G. Simon Cancer Center, Morristown, NJ, 07046, USA.
F Stephen HodiDana-Farber Cancer Institute, Boston, MA, 02215, USA.
Howard L KaufmanMassachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA. howardkaufman6@gmail.com.
Massachusetts General Hospital · USCleveland Clinic · USCarolinas Medical Center · USCity of Hope · USCommunity Health Systems - Lutheran Hospital · USDana-Farber Cancer Institute · USGeorgetown University · USHadassah Medical Center · ILLoyola University Medical Center · USMelanoma Research Foundation · USMoffitt Cancer Center · USMount Sinai Hospital · USNew York University · USProvidence Portland Medical Center · USRoswell Park Comprehensive Cancer Center · USRutgers, The State University of New Jersey · USSeattle Cancer Care Alliance · USSidney Kimmel Comprehensive Cancer Center · USTemple University · USUniversity of Chicago Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer immunotherapy has been firmly established as a standard of care for patients with advanced and metastatic melanoma. Therapeutic outcomes in clinical trials have resulted in the approval of 11 new drugs and/or combination regimens for patients with melanoma. However, prospective data to support evidence-based clinical decisions with respect to the optimal schedule and sequencing of immunotherapy and targeted agents, how best to manage emerging toxicities and when to stop treatment are not yet available.

methodsTo address this knowledge gap, the Society for Immunotherapy of Cancer (SITC) Melanoma Task Force developed a process for consensus recommendations for physicians treating patients with melanoma integrating evidence-based data, where available, with best expert consensus opinion. The initial consensus statement was published in 2013, and version 2.0 of this report is an update based on a recent meeting of the Task Force and extensive subsequent discussions on new agents, contemporary peer-reviewed literature and emerging clinical data. The Academy of Medicine (formerly Institute of Medicine) clinical practice guidelines were used as a basis for consensus development with an updated literature search for important studies published between 1992 and 2017 and supplemented, as appropriate, by recommendations from Task Force participants.

resultsThe Task Force considered patients with stage II-IV melanoma and here provide consensus recommendations for how they would incorporate the many immunotherapy options into clinical pathways for patients with cutaneous melanoma.

conclusionThese clinical guidleines provide physicians and healthcare providers with consensus recommendations for managing melanoma patients electing treatment with tumor immunotherapy.

Indexed as

Antineoplastic Agents, ImmunologicalHumansImmunotherapyMelanomaNeoplasm StagingSkin NeoplasmsAntineoplastic Agents, ImmunologicalGuidelinesImmunotherapyMelanomaTreatment

Identifiers

PMID29848375
PMCPMC5977556
OpenAlexW2806348414

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.