ArticleActa veterinaria Scandinavica2018
A porcine model for pathomorphological age assessment of surgically excised skin wounds.
Article in Acta veterinaria Scandinavica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- A multidisciplinary approach for the study of age-dependent expression patterns in porcine experimental wounds.Forensic science, medicine, and pathology · 2026Article
- Computational Quantification of Collagen Density and Ki67-Positive Cells in a Forensic Porcine Wound Model.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Digital quantification of nuclei in porcine experimental and forensic wounds: effects of wound age and body location on nuclei density.Acta veterinaria Scandinavica · 2026Article
- Does lifting female piglets by one hind leg increase the risk of umbilical and hind leg lesions?Porcine health management · 2024Article
- The detection and prediction of surgical site infections using multi-modal sensors and machine learning: Results in an animal model.Frontiers in medical technology · 2023Article
- Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
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Abstract
A porcine model of second intention wound healing was established and gross and histological changes needed for accurate assessing the age of wounds were determined. Twenty-five pigs were anesthetized before incision of four wounds on each. The wounds were left to heal from 1 h to 35 days when the pigs were euthanized. In 14 pigs, biopsies were sampled from two wounds between days 2 and 18. By histological evaluation the following characteristics were found useful for determining the age of wounds: neutrophil:macrophage ratio, angiogenesis, hyperplasia of fibroblasts, presence of hemosiderophages and granulation tissue. The latter was present from day 4 (n = 8 wounds, 100%), but by gross evaluation it was not recognized until day 5 (n = 4 wounds, 100%). From day 4 to 10, the thickness of granulation tissue increased by 1.2 ± 2.4 mm/day. The thickness of collagen fibers within granulation tissue increased throughout the study period, and complete epithelization was reached from day 18.
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