ArticleReproductive sciences (Thousand Oaks, Calif.)2019
Transcriptome-Wide Association Study Identifies Susceptibility Loci and Genes for Age at Natural Menopause.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease.Brain : a journal of neurology · 2024Article
- A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders.American journal of human genetics · 2024Article
- Challenges and Opportunities for Data Science in Women's Health.Annual review of biomedical data science · 2023Review
- Long-term changes in plasma proteomic profiles in premenopausal and postmenopausal Black and White women: the Atherosclerosis Risk in Communities study.Menopause (New York, N.Y.) · 2022Article
- Pathogenic Variants in ZSWIM7 Cause Primary Ovarian Insufficiency.The Journal of clinical endocrinology and metabolism · 2022Article
- Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis.Frontiers in endocrinology · 2022Article
- An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.Nature communications · 2020Article
- Transcriptome-wide association study identifies multiple genes and pathways associated with pancreatic cancer.Cancer medicine · 2018Article
Corrections and comments
- Erratum issuedCorrigendum.2019
Authors and funding
10 authors.
Funding
Abstract
objectiveTo identify novel susceptibility genes for age at natural menopause (ANM).
methodsUsing transcription data generated in tissues from normal hypothalami (n = 73) and ovaries (n = 68) and high-density genotyping data provided by the Genotype-Tissue Expression (GTEx) database, we built 16 164 genetic models to predict gene expression across the transcriptome in these tissues. We used these models and summary statistics data from genome-wide association studies (GWAS) of ANM generated in 69 360 women of European ancestry to identify genes with their predicted expression related to ANM.
resultsWe found the predicted expression of 34 genes to be significantly associated with ANM at a Bonferroni-corrected threshold of P < 3.09 ×10
conclusionResults from this transcriptome-wide association study, which integrated Expression quantitative trait loci (eQTL) data with summary statistics of GWAS of ANM, improves our understanding of the genetics and biology of female reproductive aging.
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