Evidence map›Paper›PMID 29847799›Full record

ArticleCell reports2018

Differentiating Cerebellar Impact on Thalamic Nuclei.

Simona V Gornati, Carmen B Schäfer, Oscar H J Eelkman Rooda, Alex L Nigg, Chris I De Zeeuw, Freek E Hoebeek

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. tACS of the Cerebellum and the Motor Cortex Entrains the Spiking Activity of the Cells in Motor Thalamus in a Frequency Dependent Manner.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Synergistic Reinforcement Learning by Cooperation of the Cerebellum and Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Simona V GornatiDepartment of Neuroscience, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands.
Carmen B SchäferDepartment of Neuroscience, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands.
Oscar H J Eelkman RoodaDepartment of Neuroscience, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands; Department of Neurosurgery, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands.
Alex L NiggDepartment of Pathology, Optical Imaging Center, Erasmus MC, 3015 AA Rotterdam, The Netherlands.
Chris I De ZeeuwDepartment of Neuroscience, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands; Netherlands Institute for Neuroscience, Royal Academy for Arts and Sciences, 1105 BA Amsterdam, The Netherlands.
Freek E HoebeekDepartment of Neuroscience, Erasmus Medical Center, 3015 AA Rotterdam, The Netherlands; NIDOD Institute, Wilhelmina Children's Hospital and Brain Center Rudolf Magnus, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands. Electronic address: f.e.hoebeek@umcutrecht.nl.
Erasmus MC · NLErasmus University Rotterdam · NLNetherlands Institute for Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cerebellum plays a role in coordination of movements and non-motor functions. Cerebellar nuclei (CN) axons connect to various parts of the thalamo-cortical network, but detailed information on the characteristics of cerebello-thalamic connections is lacking. Here, we assessed the cerebellar input to the ventrolateral (VL), ventromedial (VM), and centrolateral (CL) thalamus. Confocal and electron microscopy showed an increased density and size of CN axon terminals in VL compared to VM or CL. Electrophysiological recordings in vitro revealed that optogenetic CN stimulation resulted in enhanced charge transfer and action potential firing in VL neurons compared to VM or CL neurons, despite that the paired-pulse ratio was not significantly different. Together, these findings indicate that the impact of CN input onto neurons of different thalamic nuclei varies substantially, which highlights the possibility that cerebellar output differentially controls various parts of the thalamo-cortical network.

Indexed as

AnimalsAxonsCerebellar NucleiCerebellumDendritesElectric StimulationExcitatory Postsynaptic PotentialsFemaleMaleMice, Inbred C57BLReceptors, Ionotropic GlutamateSynapsesSynaptic TransmissionThalamic NucleiReceptors, Ionotropic Glutamatecerebellar nucleimorphologyoptogeneticssynaptic transmissionthalamus

Identifiers

PMID29847799
PMCPMC5990493
OpenAlexW2805565663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.