ArticleCell reports2018
Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Sex Differences in Auditory Brainstem Responses of Two Rat Models of Autism: Environmental and Genetic Contributions to Autism-Like Auditory Function.Autism research : official journal of the International Society for Autism Research · 2025Article
- Dendritic beading during early brain development impairs signal transmission and synaptic plasticity.Acta neuropathologica communications · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms.Neurobiology of stress · 2024Review
- Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.Brain : a journal of neurology · 2024Article
- Gene-environmental regulation of the postnatal post-mitotic neuronal maturation.Trends in genetics : TIG · 2024Review
- Reversible synaptic adaptations in a subpopulation of murine hippocampal neurons following early-life seizures.The Journal of clinical investigation · 2024Article
- Dysregulation of GABAA Receptor-Mediated Neurotransmission during the Auditory Cortex Critical Period in the Fragile X Syndrome Mouse Model.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Occlusion of activity dependent synaptic plasticity by late hypoxic long term potentiation after neonatal intermittent hypoxia.Experimental neurology · 2021Review
- Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders.Frontiers in neural circuits · 2021Review
- EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas.Brain structure & function · 2020Article
- Regulation of auditory plasticity during critical periods and following hearing loss.Hearing research · 2020Review
- Critical period regulation across multiple timescales.Proceedings of the National Academy of Sciences of the United States of America · 2020Review
- Early life stress facilitates synapse premature unsilencing to enhance AMPA receptor function in the developing hippocampus.Journal of neurophysiology · 2020Article
- Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson's disease.Molecular brain · 2020Article
- Silent Synapse-Based Mechanisms of Critical Period Plasticity.Frontiers in cellular neuroscience · 2020Review
- Article
- Early-life adversity and neurological disease: age-old questions and novel answers.Nature reviews. Neurology · 2019Review
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6 authors at 3 institutions in 2 countries.
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Abstract
Heightened neural excitability in infancy and childhood results in increased susceptibility to seizures. Such early-life seizures are associated with language deficits and autism that can result from aberrant development of the auditory cortex. Here, we show that early-life seizures disrupt a critical period (CP) for tonotopic map plasticity in primary auditory cortex (A1). We show that this CP is characterized by a prevalence of "silent," NMDA-receptor (NMDAR)-only, glutamate receptor synapses in auditory cortex that become "unsilenced" due to activity-dependent AMPA receptor (AMPAR) insertion. Induction of seizures prior to this CP occludes tonotopic map plasticity by prematurely unsilencing NMDAR-only synapses. Further, brief treatment with the AMPAR antagonist NBQX following seizures, prior to the CP, prevents synapse unsilencing and permits subsequent A1 plasticity. These findings reveal that early-life seizures modify CP regulators and suggest that therapeutic targets for early post-seizure treatment can rescue CP plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.