Evidence map›Paper›PMID 29847696›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2018

Inverse Opal Scaffolds with Gradations in Mineral Content for Spatial Control of Osteogenesis.

Chunlei Zhu, Jichuan Qiu, Suphannee Pongkitwitoon, Stavros Thomopoulos, Younan Xia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 50 citations in OpenAlex.

  1. BiomimeticBioactive materials · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chunlei ZhuThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Jichuan QiuThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Suphannee PongkitwitoonDepartment of Orthopaedic Surgery, Columbia University, New York, NY, 10032, USA.
Stavros ThomopoulosDepartment of Orthopaedic Surgery, Columbia University, New York, NY, 10032, USA.
Younan XiaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.ORCID http://orcid.org/0000-0002-6530-0632
Georgia Institute of Technology · USColumbia University · US

Funding

Nanofiber Scaffolds with Gradations in Mineral Content for Rotator Cuff RepairR01AR060820 · NIAMS · WASHINGTON UNIVERSITY · PI GALATZ, LEESA M, THOMOPOULOS, STAVROS · 2011 to 2015
$2.2M
NIAMS NIH HHS R01 AR060820
6 · The paper itself

Abstract

The design and fabrication of inverse opal scaffolds with gradations in mineral content to achieve spatial control of osteogenesis are described. The gradient in mineral content is established via the diffusion-limited transport of hydroxyapatite nanoparticles in a closely packed lattice of gelatin microbeads. The mineral-graded scaffold has an array of uniform pores and interconnected windows to facilitate efficient transport of nutrients and metabolic wastes, ensuring high cell viability. The graded distribution of mineral content can provide biochemical and mechanical cues for spatially regulating the osteogenic differentiation of adipose-derived stromal cells. This new class of scaffolds holds promise for engineering the interfaces between mineralized and unmineralized tissues.

Indexed as

graded mineralizationinterfacial tissue engineeringinverse opal scaffoldsmineral gradientosteogenesis

Identifiers

PMID29847696
PMCPMC6269221
OpenAlexW2806648804

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.