ArticleInvestigative ophthalmology & visual science2018
Aqueous Humor Dynamics of the Brown-Norway Rat.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Circadian Norepinephrine Rhythm Regulates Outflow Facility and IOP in Rat Eyes.Investigative ophthalmology & visual science · 2026Article
- Anti-VEGF Agents Clearance Through the Aqueous Outflow Pathway in a Rat Model.Investigative ophthalmology & visual science · 2025Article
- Effect of Ambient Lighting on Intraocular Pressure Rhythms in Rats.Investigative ophthalmology & visual science · 2024Article
- Characterization of intraocular pressure variability in conscious rats.Experimental eye research · 2024Article
- A portable feedback-controlled pump for monitoring eye outflow facility in conscious rats.PloS one · 2023Article
- Simulation of gravity- and pump-driven perfusion techniques for measuring outflow facility of ex vivo and in vivo eyes.PloS one · 2023Article
- Evaluation of trabecular meshwork-specific promotersInternational journal of ophthalmology · 2023Article
- Perioperative Care of the Patient with Eye Pathologies Undergoing Nonocular Surgery.Anesthesiology · 2022Article
- Measurement of postmortem outflow facility using iPerfusion.Experimental eye research · 2022Article
- Anterior Segment Anatomy and Conventional Outflow Physiology of the Tree Shrew (Tupaia belangeri).Investigative ophthalmology & visual science · 2022Article
- Effects of acute stress, general anesthetics, tonometry, and temperature on intraocular pressure in rats.Experimental eye research · 2021Article
- Age and Menopause Effects on Ocular Compliance and Aqueous Outflow.Investigative ophthalmology & visual science · 2020Article
- Experimental glaucoma model with controllable intraocular pressure history.Scientific reports · 2020Article
- Intracranial pressure modulates aqueous humour dynamics of the eye.The Journal of physiology · 2020Article
- Detection and characterization of tree shrew retinal venous pulsations: An animal model to study human retinal venous pulsations.Experimental eye research · 2019Article
- Measurement of Ocular Compliance Using iPerfusion.Frontiers in bioengineering and biotechnology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Purpose: The study aimed to provide a quantitative description of aqueous humor dynamics in healthy rat eyes. Methods: One eye of 26 anesthetized adult Brown-Norway rats was cannulated with a needle connected to a perfusion pump and pressure transducer. Pressure-flow data were measured in live and dead eyes by varying pump rate (constant-flow technique) or by modulating pump duty cycle to hold intraocular pressure (IOP) at set levels (modified constant-pressure technique). Data were fit by the Goldmann equation to estimate conventional outflow facility (C) and unconventional outflow rate (Fun). Parameter estimates were respectively checked by inserting a shunt of similar conductance into the eye and by varying eye hydration methodology. Results: Rat IOP averaged 14.6 ± 1.9 mm Hg at rest. Pressure-flow data were repeatable and indistinguishable for the two perfusion techniques, yielding C = 0.023 ± 0.002 μL/min/mm Hg and Fun = 0.096 ± 0.024 μL/min. C was similar for live and dead eyes and increased upon shunt insertion by an amount equal to shunt conductance, validating measurement accuracy. At 100% humidity Fun dropped to 0.003 ± 0.030 μL/min. Physiological washout was not observed (-0.35 ± 0.65%/h), and trabecular anatomy looked normal. Conclusions: Rat aqueous humor dynamics are intermediate in magnitude compared to those in mice and humans, consistent with species differences in eye size. C does not change with time or death. Evaporation complicates measurement of Fun even when eyes are not enucleated. Absence of washout is a notable finding seen only in mouse and human eyes to date.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.