ArticleInvestigative ophthalmology & visual science2018
Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.
Article in Investigative ophthalmology & visual science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Effect of Deep Optic Nerve Head Morphology on Lamina Cribrosa and Peripapillary Scleral Configurations in Healthy Eyes.Investigative ophthalmology & visual science · 2025Article
- Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements.Investigative ophthalmology & visual science · 2024Article
- Lamina Cribrosa Configurations in Highly Myopic and Non-Highly Myopic Eyes: The Beijing Eye Study.Investigative ophthalmology & visual science · 2024Article
- Effect of Eye Globe and Optic Nerve Morphologies on Gaze-Induced Optic Nerve Head Deformations.Investigative ophthalmology & visual science · 2024Article
- OCT Optic Nerve Head Morphology in Myopia IV: Neural Canal Scleral Flange Remodeling in Highly Myopic Eyes.American journal of ophthalmology · 2024Article
- Optical Coherence Tomographic Optic Nerve Head Morphology in Myopia III: The Exposed Neural Canal Region in Healthy Eyes-Implications for High Myopia.American journal of ophthalmology · 2024Article
- Displacement of the Lamina Cribrosa With Acute Intraocular Pressure Increase in Brain-Dead Organ Donors.Investigative ophthalmology & visual science · 2023Article
- OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia-An American Ophthalmological Society Thesis.American journal of ophthalmology · 2023Article
- Deep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length.American journal of ophthalmology · 2023Observational
- Under Pressure: Lamina Cribrosa Pore Path Tortuosity in Response to Acute Pressure Modulation.Translational vision science & technology · 2023Article
- Comparison of lamina cribrosa depth shallowing after trabeculectomy between primary open-angle glaucoma and exfoliation glaucoma.Scientific reports · 2022Article
- Detection of superficial and buried optic disc drusen with swept-source optical coherence tomography.BMC ophthalmology · 2022Article
- Nonlinear distortion correction for posterior eye segment optical coherence tomography with application to tree shrews.Biomedical optics express · 2022Article
- Offset of openings in optic nerve head canal at level of Bruch's membrane, anterior sclera, and lamina cribrosa.Scientific reports · 2021Article
- Association of Optic Nerve Head Prelaminar Schisis With Glaucoma.American journal of ophthalmology · 2021Article
- Optical Coherence Tomography Imaging of the Lamina Cribrosa: Structural Biomarkers in Nonglaucomatous Diseases.Journal of ophthalmology · 2021Review
- Optical Coherence Tomography Optic Nerve Head Morphology in Myopia I: Implications of Anterior Scleral Canal Opening Versus Bruch Membrane Opening Offset.American journal of ophthalmology · 2020Article
- Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes.American journal of ophthalmology · 2020Article
- Optical Coherence Tomography Structural Abnormality Detection in Glaucoma Using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria.American journal of ophthalmology · 2020Article
- Relationship of Corneal Hysteresis and Anterior Lamina Cribrosa Displacement in Glaucoma.American journal of ophthalmology · 2020Observational
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 4 countries.
Funding
Abstract
Purpose: To quantify the influence of ocular and demographic factors on central laminar depth (LD) in healthy participants. Methods: A total of 362 normal subjects underwent optical coherence tomography (OCT) enhanced depth imaging of the optic nerve head (ONH) with a 24 radial B-scan pattern aligned to the fovea-to-Bruch's membrane opening (BMO) axis. BMO, anterior lamina, anterior scleral canal opening (ASCO), Bruch's membrane (BM), and the peripapillary scleral surface were manually segmented. The extent of laminar segmentation was quantified within 72 ASCO subsectors. Central LD was quantified relative to four reference planes: BMO, ASCO, BM, and scleral. The effects of age, sex, ethnicity, IOP, BMO area, ASCO area, and axial length on LD were assessed. Results: Laminar visibility was most consistent within the central ASCO (median 89%, range, 69%-95%). LDBMO and LDBM were significantly shallower in eyes with greater age, BMO area, and axial length and in females. LDASCO was shallower in eyes with greater ASCO area and axial length and in European and Hispanic descent compared to African descent eyes. LDSclera behaved similarly, but was not associated with axial length. BMO and ASCO area were not different between African descent and European descent eyes. Conclusions: Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera. However, the magnitude of these effects for all four reference planes was small, and their clinical importance in the detection of glaucoma and its progression remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.