ArticleJournal of acquired immune deficiency syndromes (1999)2018
Does Partner Selection Mediate the Relationship Between School Attendance and HIV/Herpes Simplex Virus-2 Among Adolescent Girls and Young Women in South Africa: An Analysis of HIV Prevention Trials Network 068 Data.
Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Developmental Trajectories of Transactional Sex and Age-Disparate Relationships During Adolescence: An HPTN 068 Analysis.AIDS and behavior · 2024Trial
- Sexual Relationship Typologies, Multilevel Determinants, and HIV Among Adolescent Mothers in Eastern and Southern Africa: A Multilevel Latent Class Analysis.AIDS and behavior · 2026Article
- Stress-responsive biomarkers and sexual behaviors among young women in rural South Africa.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- School Dropout, Absenteeism and Coverage of Sexual and Reproductive Health Services in South Africa: Are Those Most at Risk Reached?AIDS and behavior · 2024Article
- Article
- Tough Talks COVID-19 Digital Health Intervention for Vaccine Hesitancy Among Black Young Adults: Protocol for a Hybrid Type 1 Effectiveness Implementation Randomized Controlled Trial.JMIR research protocols · 2023Article
- Modeling Combination Interventions to Prevent Human Immunodeficiency Virus in Adolescent Girls and Young Women in South Africa (HIV Prevention Trials Network 068).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Spillover HIV prevention effects of a cash transfer trial in East Zimbabwe: evidence from a cluster-randomised trial and general-population survey.BMC public health · 2020Article
- The effects of a cash transfer intervention on sexual partnerships and HIV in the HPTN 068 study in South Africa.Culture, health & sexuality · 2020Article
- Variations in HIV Risk by Young Women's Age and Partner Age Disparity in Rural South Africa (HPTN 068).Journal of acquired immune deficiency syndromes (1999) · 2020Article
- The Mediating Role of Partner Selection in the Association Between Transactional Sex and HIV Incidence Among Young Women.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Multilevel Measures of Education and Pathways to Incident Herpes Simplex Virus Type 2 in Adolescent Girls and Young Women in South Africa.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 5 countries.
Funding
Abstract
objectiveSchool attendance prevents HIV and herpes simplex virus-2 (HSV-2) in adolescent girls and young women, but the mechanisms to explain this relationship remain unclear. Our study assesses the extent to which characteristics of sex partners, partner age, and number mediate the relationship between attendance and risk of infection in adolescent girls and young women in South Africa.
designWe use longitudinal data from the HIV Prevention Trials Network 068 randomized controlled trial in rural South Africa, where girls were enrolled in early adolescence and followed in the main trial for more than 3 years. We examined older partners and the number of partners as possible mediators.
methodsWe used the parametric g-formula to estimate 4-year risk differences for the effect of school attendance on the cumulative incidence of HIV/HSV-2 overall and the controlled direct effect (CDE) for mediation. We examined mediation separately and jointly for the mediators of interest.
resultsWe found that young women with high attendance in school had a lower cumulative incidence of HIV compared with those with low attendance (risk difference = -1.6%). Partner age difference (CDE = -1.2%) and the number of partners (CDE = -0.4%) mediated a large portion of this effect. In fact, when we accounted for the mediators jointly, the effect of schooling on HIV was almost removed, showing full mediation (CDE = -0.3%). The same patterns were observed for the relationship between school attendance and cumulative incidence of HSV-2 infection.
conclusionIncreasing school attendance reduces the risk of acquiring HIV and HSV-2. Our results indicate the importance of school attendance in reducing partner number and partner age difference in this relationship.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.