Evidence map›Paper›PMID 29846831›Full record

ArticleLasers in medical science2018

Application of cationized magnetoferritin for magnetic field-assisted delivery of short interfering RNA in vitro.

Melánia Babincová, Štefan Durdík, Natália Babincová, Paul Sourivong, Peter Babinec

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Monitoring of the choline/lipid ratio byLasers in medical science · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Melánia BabincováDepartment of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F1, 842 48, Bratislava, Slovakia.
Štefan DurdíkDepartment of Surgical Oncology, Saint Elisabeth Cancer Institute and Faculty of Medicine, Comenius University Bratislava, Heydukova 10, Bratislava, Slovakia.
Natália BabincováDepartment of Dermatovenerology, Faculty of Medicine, Mickiewiczova 13, 813 69, Bratislava, Slovakia.
Paul SourivongOklahoma Cancer Specialists and Research Institute, 12697 East 51st Street South, Tulsa, OK, 74146, USA.
Peter BabinecDepartment of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, Mlynská dolina F1, 842 48, Bratislava, Slovakia. babinec@fmph.uniba.sk.
Comenius University Bratislava · SKOklahoma Cancer Specialists and Research Institute · USSlovak Medical University · SK

Funding

Agentúra na Podporu Výskumu a Vývoja APVV-16-0600Slovak grant agency VEGA 1/0810/18
6 · The paper itself

Abstract

Cationized magnetoferritin is used for development of a simple, efficient, and fast delivery of short interference RNA into cells using combination of magnetophoresis for pre-concentration of siRNA-magnetoferritin complex on the surface of plated cells with subsequent application of nanosecond laser pulses producing stress waves in transfection chamber, which permeabilize cell membrane for the facilitated delivery of siRNA into the cell interior. As has been quantified using siRNA inducing cell death assay, by combination of these two physical factors we have obtained high efficiency for tested three different human carcinoma cells. Proposed method of gene silencing based on cationized magnetoferritin is a versatile and easily accessible platform with many possible applications in gene therapy.

Indexed as

Magnetic FieldsApoferritinsCationsCell DeathCell Line, TumorCell SurvivalGene SilencingGenetic TherapyHumansIronOxidesRNA, Small InterferingTransfectionApoferritinsCationsIronmagnetoferritinOxidesRNA, Small InterferingCell transfectionInterference RNALaser pulsesMagnetoferritinMagnetophoresis

Identifiers

PMID29846831
OpenAlexW2806476101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.