ArticlePlanta2018
The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis.
Article in Planta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Transcriptional adapter ADA2 regulates yield and end-use quality through liquid-liquid phase separation in wheat.Journal of integrative plant biology · 2026Article
- C2H2 Zinc Finger Proteins GIS2 and ZFP8 Regulate Trichome Development via Hormone Signaling in Arabidopsis.International journal of molecular sciences · 2025Article
- GCN5-related histone acetyltransferase HOOKLESS2 regulates fungal resistance and growth in tomato.The New phytologist · 2025Article
- Roles of Histone Acetylation and Deacetylation in Root Development.Plants (Basel, Switzerland) · 2024Review
- Gibberellin Signaling through RGA Suppresses GCN5 Effects on Arabidopsis Developmental Stages.International journal of molecular sciences · 2024Article
- ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels.Plant biotechnology journal · 2024Article
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- Article
- Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review.Horticulture research · 2023Article
- SUB1A-1 anchors a regulatory cascade for epigenetic and transcriptional controls of submergence tolerance in rice.PNAS nexus · 2023Article
- Multi-Dimensional Molecular Regulation of Trichome Development inFrontiers in plant science · 2022Review
- Histone acetylation dynamics regulating plant development and stress responses.Cellular and molecular life sciences : CMLS · 2021Review
- Review
- Article
- The Histone Acetyltransferase GCN5 and the Associated Coactivators ADA2: From Evolution of the SAGA Complex to the Biological Roles in Plants.Plants (Basel, Switzerland) · 2021Review
- GCN5 modulates salicylic acid homeostasis by regulating H3K14ac levels at the 5' and 3' ends of its target genes.Nucleic acids research · 2020Article
- Identification of Homeobox Genes Associated with Lignification and Their Expression Patterns in Bamboo Shoots.Biomolecules · 2019Article
- The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect trichome initiation inmicroPublication biology · 2019Article
- Disruption of the histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect trichome density inmicroPublication biology · 2019Article
- Expression of the DELLA repressor GAI and its regulators SPY and SEC are impacted by disruption of chromatin modifiers.microPublication biology · 2019Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionThe histone acetyltransferase GCN5 and associated transcriptional coactivator ADA2b are required to couple endoreduplication and trichome branching. Mutation of ADA2b also disrupts the relationship between ploidy and leaf cell size. Dynamic chromatin structure has been established as a general mechanism by which gene function is temporally and spatially regulated, but specific chromatin modifier function is less well understood. To address this question, we have investigated the role of the histone acetyltransferase GCN5 and the associated coactivator ADA2b in developmental events in Arabidopsis thaliana. Arabidopsis plants with T-DNA insertions in GCN5 (also known as HAG1) or ADA2b (also known as PROPORZ1) display pleiotropic phenotypes including dwarfism and floral defects affecting fertility. We undertook a detailed characterization of gcn5 and ada2b phenotypic effects in rosette leaves and trichomes to establish a role for epigenetic control in these developmental processes. ADA2b and GCN5 play specific roles in leaf tissue, affecting cell growth and division in rosette leaves often in complex and even opposite directions. Leaves of gcn5 plants display overall reduced ploidy levels, while ada2b-1 leaves show increased ploidy. Endoreduplication leading to increased ploidy is also known to contribute to normal trichome morphogenesis. We demonstrate that gcn5 and ada2b mutants display alterations in the number and patterning of trichome branches, with ada2b-1 and gcn5-1 trichomes being significantly less branched, while gcn5-6 trichomes show increased branching. Elongation of the trichome stalk and branches also vary in different mutant backgrounds, with stalk length having an inverse relationship with branch number. Taken together, our data indicate that, in Arabidopsis, leaves and trichomes ADA2b and GCN5 are required to couple nuclear content with cell growth and morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.