ArticleThe Journal of clinical endocrinology and metabolism2018
Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.
Article in The Journal of clinical endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Transcriptome Profiling of Adipose Tissue Reveals Depot-Specific Metabolic Alterations Among Patients with Colorectal Cancer.The Journal of clinical endocrinology and metabolism · 2019Trial
- A distinct form of fat fibrosis is linked to insulin resistance in people with HIV.JCI insight · 2026Observational
- Abdominal Adipose Tissue Fibrosis as an Obesity Biomarker in Clinical Practice.Obesity facts · 2026Article
- Distinct precursor landscape of subcutaneous and visceral fat in development and aging.Cell reports · 2026Review
- A Preliminary Study on Factors That Drive Patient Variability in Human Subcutaneous Adipose Tissues.Cells · 2024Article
- Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities.The Journal of clinical endocrinology and metabolism · 2022Article
- The shades of grey in adipose tissue reprogramming.Bioscience reports · 2022Review
- Large mid-upper arm circumference is associated with reduced insulin resistance independent of BMI and waist circumference: A cross-sectional study in the Chinese population.Frontiers in endocrinology · 2022Article
- Assessing Obesity-Related Adipose Tissue Disease (OrAD) to Improve Precision Medicine for Patients Living With Obesity.Frontiers in endocrinology · 2022Review
- Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- The multifaceted progenitor fates in healthy or unhealthy adipose tissue during obesity.Reviews in endocrine & metabolic disorders · 2021Review
- The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health.eLife · 2021Article
- Effects of short-term calorie restriction on circulating DPP-4/sCD26 concentrations and body composition in patients with type 2 diabetes.Diabetology international · 2021Article
- Exercise retards ongoing adipose tissue fibrosis in diet-induced obese mice.Endocrine connections · 2021Article
- Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity.Frontiers in nutrition · 2021Review
- PI3K/Akt pathway expression in children with different obesity degrees and its relationship with glucolipid metabolism and insulin resistance.American journal of translational research · 2021Article
- Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases.Molecular biology reports · 2020Review
- Adipose Tissue Fibrosis: Mechanisms, Models, and Importance.International journal of molecular sciences · 2020Review
- Article
- Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria.Nature microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Objective: Type 2 diabetes presents at a lower body mass index (BMI) in Chinese individuals than in white individuals. We sought to determine the role of subcutaneous adipose tissue (SCAT)-intrinsic factors, vs BMI or adiposity per se, in the vulnerability of Chinese individuals to obesity-associated impairment of insulin sensitivity. Research Design and Methods: Thirty-two Chinese and 30 white men and women from a cohort in the San Francisco Bay Area underwent anthropometric measurements, body composition (dual-energy X-ray absorptiometry) analyses, and measurement of fasting plasma glucose and insulin. Forty-eight also provided abdominal SCAT samples for transcriptional and biochemical analyses of tissue fibrosis. Results: BMI correlated with total body fat in white (r = 0.74, P < 0.001) but not Chinese individuals, whereas BMI correlated with visceral adipose tissue (VAT) accrual in both ethnicities (r = 0.88 and 0.81, respectively; P < 0.01). Insulin resistance (homeostatic model assessment of insulin resistance) worsened with VAT mass, but not total body fat, in Chinese subjects (r = 0.63, P < 0.01), whereas it worsened with both in white individuals. By contrast, SCAT mRNA levels of genes encoding profibrotic proteins rose remarkably along with both BMI and VAT mass in Chinese but not white subjects. Similarly, SCAT levels of hydroxyproline, an indicator of tissue collagen content that correlated with increasing VAT mass, were higher in Chinese vs white subjects, particularly in the setting of relative insulin resistance. Conclusions: Our findings dissociate BMI from adiposity in Chinese individuals and instead highlight SCAT fibrosis as a process linked to visceral adiposity and insulin resistance in this group.
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Registered trials
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