ArticleFEMS microbiology letters2018
Ciprofloxacin binding to GyrA causes global changes in the proteome of Pseudomonas aeruginosa.
Article in FEMS microbiology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Exploring the potential role of GyrA inhibiting quinoline analog: an in silico study.Scientific reports · 2025Article
- Streptozotocin-Induced Hyperglycemia Is Associated with Unique Microbiome Metabolomic Signatures in Response to Ciprofloxacin Treatment.Antibiotics (Basel, Switzerland) · 2022Article
- Ciprofloxacin induced antibiotic resistance in Salmonella Typhimurium mutants and genome analysis.Archives of microbiology · 2021Article
- Sub-Inhibitory Antibiotic Exposure and Virulence inAntibiotics (Basel, Switzerland) · 2021Review
- An Evaluation of the Antibacterial Properties of Tormentic Acid Congener and Extracts FromAdvances in pharmacological and pharmaceutical sciences · 2020Article
- Detection of virulence and multidrug resistance operons inVeterinary world · 2019Article
- A Pilot Study of the Synergy between Two Antimicrobial Peptides and Two Common Antibiotics.Antibiotics (Basel, Switzerland) · 2019Article
- Mutations inInfection and drug resistance · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Ciprofloxacin is one of the most widely-used antibiotics, and has proven especially effective at controlling infections associated with the opportunistic human pathogen, Pseudomonas aeruginosa. In this work, we show that sub-inhibitory concentrations of ciprofloxacin induce discrete changes in the intracellular proteome. Central metabolism and cell envelope-associated functions are particularly affected. In spite of the low magnitude of the intracellular proteomic changes, we found that sub-lethal concentrations of ciprofloxacin had substantial effects on motility and exoprotein secretion. Crucially, the proteomic and phenotypic modulations that we observed were absolutely dependent upon the presence of wild-type GyrA; an isogenic strain of P. aeruginosa carrying a ciprofloxacin-insensitive form of GyrA (a T83→I mutant) did not display ciprofloxacin-dependent changes unless complemented with wild-type gyrA in trans. These results show that the diverse effects of sub-inhibitory ciprofloxacin on the cell are routed through its primary target in the cell, DNA gyrase.
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Registered trials
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