ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Longitudinal Relationship Between Interleukin-6 and Perceived Fatigability Among Well-Functioning Adults in Mid-to-Late Life.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Effects of Psychosocial Interventions and Caregiving Stress on Cardiovascular Biomarkers in Family Dementia Caregivers: The UCSD Pleasant Events Program (PEP) Randomized Controlled Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Fatigue, muscle fatigability, and the Hallmarks of Aging: a narrative review.The journal of nutrition, health & aging · 2026Review
- Pathogenic Crosstalk Between the Peripheral and Central Nervous System in Rheumatic Diseases: Emerging Evidence and Clinical Implications.International journal of molecular sciences · 2025Review
- Associations of depression and perceived physical fatigability with white matter integrity in older adults.Psychiatry research. Neuroimaging · 2024Article
- Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices.Scientific reports · 2023Article
- Measuring and Understanding the Health Impact of Greater Fatigability in Older Adults: A Call to Action and Opportunities.Fatigue : biomedicine, health & behavior · 2023Article
- Changes in Objectively Measured Physical Activity Are Associated With Perceived Physical and Mental Fatigability in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Article
- Home-based exercise program in the indeterminate form of Chagas disease (PEDI-CHAGAS study): A study protocol for a randomized clinical trial.Frontiers in medicine · 2022Article
- Traits and treadmills: Association between personality and perceived fatigability in well-functioning community-dwelling older adults.Psychology and aging · 2021Article
- Profiles of Accelerometry-Derived Physical Activity Are Related to Perceived Physical Fatigability in Older Adults.Sensors (Basel, Switzerland) · 2021Article
- Fatigability as a Predictor of Subclinical and Clinical Anemia in Well-Functioning Older Adults.Journal of the American Geriatrics Society · 2020Article
- Longitudinal Association Between Perceived Fatigability and Cognitive Function in Older Adults: Results from the Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Fatigability: A Prognostic Indicator of Phenotypic Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Associations of Actigraphic Sleep Parameters With Fatigability in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Longitudinal Association Between Energy Regulation and Fatigability in Mid-to-Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Association Between Cardiovascular Risk and Perceived Fatigability in Mid-to-Late Life.Journal of the American Heart Association · 2019Article
- Association Between Adiposity and Perceived Physical Fatigability in Mid- to Late Life.Obesity (Silver Spring, Md.) · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundChronically elevated interleukin-6 (IL-6) levels contribute to fatigue and functional decline via multiple pathways that often lead to frailty. Lesser known is the contribution of IL-6 to fatigue in relation to a standardized workload (fatigability), a precursor to functional decline. Therefore, the purpose of this study was to examine the longitudinal relationship between IL-6 and fatigability.
methodsAbout 985 participants from the Baltimore Longitudinal Study of Aging (mean age: 70 ± 10 years) were evaluated every 1-4 years. IL-6 was measured in fasting serum samples at each visit and log-transformed for analyses. Perceived fatigability (PF) was defined as self-reported exertion (rate of perceived exertion; RPE) after a 5-min, 0.67 m/s, 0% grade treadmill walk. Continuous and categorical associations between IL-6 (baseline and repeated measures) and PF were assessed using generalized estimating equations, adjusting for demographics, behavioral factors, and comorbid conditions.
resultsIn fully adjusted continuous models, twofold higher baseline IL-6 was associated with a 0.28 higher RPE (p = .03). This relationship tended to remain constant annually (baseline log IL-6 by time interaction p = .29). To provide clinical relevance, the sample median (3.7 pg/mL) was used to examine high versus low IL-6 levels. Over time, the high group reported an average 0.25 higher RPE (p = .03) than the low group. Annual change in logged IL-6 was not associated with annual change in PF (p = .48).
conclusionFindings suggest that elevated IL-6 is a biomarker of physiological dysregulation associated with greater fatigability, but there is no longitudinal association between IL-6 and fatigability. Future studies should evaluate whether interventions that aim to reduce inflammation also attenuate fatigability.
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