ReviewRevista do Instituto de Medicina Tropical de Sao Paulo2018
Pathology and pathogenesis of human leptospirosis: a commented review.
Review in Revista do Instituto de Medicina Tropical de Sao Paulo, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 129 citations in OpenAlex.
- Epidemiology of leptospirosis in Tanzania: A review of the current status, serogroup diversity and reservoirs.PLoS neglected tropical diseases · 2021Pooled it
- Article
- Leptospirosis-associated meningitis in an urban tropical endemic setting in northeastern Brazil: Three New cases and a meta-summary of 176 reported cases.PLoS neglected tropical diseases · 2026Article
- An Unexpected Cause of Extreme Hyperbilirubinemia and Acute Renal Failure: A Case of Weil's Disease in Poland.Cureus · 2026Article
- The Pattern and Distribution of Ventilatory Defects after Extracorporeal Membrane Oxygenation in Survivors of Leptospirosis with Acute Respiratory Distress Syndrome: A Single-center Cross-sectional Study.Acta medica Philippina · 2026Article
- A Life-Threatening Case of Severe Leptospirosis in Wales, UK: Recognising Severe Disease in Non-endemic Settings.Cureus · 2025Article
- Different clinical profile of leptospirosis in a tertiary care Indian hospital: A Himalayan experience.World journal of clinical cases · 2025Article
- Tackling the ST elevation in leptospirosis: A double-edged sword between bleeding and thrombosis - A case report.Narra J · 2025Article
- Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis.Emerging infectious diseases · 2025Article
- Accuracy of four rapid diagnostic tests (RDTs) for human leptospirosis diagnosis in Indonesia.Microbiology spectrum · 2025Article
- Leptospirosis.Nature reviews. Disease primers · 2025Review
- Bowel Necrosis in Leptospirosis: A Case Series of a Rare Complication.Case reports in infectious diseases · 2025Article
- Severe Leptospirosis with Apyrexia and an Atypical Presentation: Rapid Progression to Multi-Organ Failure.European journal of case reports in internal medicine · 2025Article
- Gastrointestinal mucormycosis associated with leptospirosis: should we be concerned during major floods?Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Leptospirosis and coinfections leading to fatal multiple organ and system failure.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Leptospirosis outbreak in Ecuador in 2023: A pilot study for surveillance from a One Health perspective.One health (Amsterdam, Netherlands) · 2024Article
- Under-Reporting of Human Leptospirosis Cases in Cities of Triângulo Mineiro, Minas Gerais, Brazil.Tropical medicine and infectious disease · 2024Article
- Leptospirosis Incidence Post-Flooding Following Storm Daniel: The First Case Series in Greece.Infectious disease reports · 2024Article
- Clinical presentation of human leptospirosis in febrile patients: Urabá, Colombia.PLoS neglected tropical diseases · 2024Observational
- Exudative glomerulonephritis associated with acute leptospirosis in dogs.Veterinary pathology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil contaminated with urine from infected animals. Leptospires enter the body by penetrating mucous membranes or skin abrasions and disseminate through the hematogenic route. In humans, leptospirosis may cause a wide spectrum of symptoms. Most cases have a biphasic clinical presentation, which begins with the septicemic phase followed by immune manifestations. The severe forms of the disease may be life threatening with multisystem damage including renal failure, hepatic dysfunction, vascular damage, pulmonary hemorrhage and muscle lesions. In this review, we present and discuss the pathogenesis of the human disease and the mechanisms of cell membrane injuries, which occur mainly due to the presence of leptospires and/or their antigen/s in the host tissues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.