ArticleAmerican journal of physiology. Renal physiology2018
Prevention of the progression of renal injury in diabetic rodent models with preexisting renal disease with chronic endothelin A receptor blockade.
Open access · bronzeAbstract read
In one paragraph
Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Impact of intrarenal arterial lesions on prognosis of IgA nephropathy: insights from a retrospective cohort study.Renal failure · 2025Article
- mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt-sensitive rats before puberty.Experimental physiology · 2025Article
- Selective endothelin A receptor antagonism in chronic kidney disease: improving clinical application.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Abatacept Decreases Renal T-cell Infiltration and Renal Inflammation and Ameliorates Progressive Renal Injury in Obese Dahl Salt-sensitive Rats Before Puberty.Journal of cardiovascular pharmacology · 2024Article
- Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats.American journal of physiology. Renal physiology · 2023Article
- Kidney fibrosis: from mechanisms to therapeutic medicines.Signal transduction and targeted therapy · 2023Review
- Neutralizing MIP3The Journal of pharmacology and experimental therapeutics · 2023Article
- Endothelin Receptor Antagonists in Kidney Disease.International journal of molecular sciences · 2023Review
- Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice.Canadian journal of physiology and pharmacology · 2022Article
- The SSAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Endothelin receptors in renal interstitial cells do not contribute to the development of fibrosis during experimental kidney disease.Pflugers Archiv : European journal of physiology · 2021Article
- The NaCellular and molecular life sciences : CMLS · 2021Review
- Sexual dimorphism in the progression of type 2 diabetic kidney disease in T2DN rats.Physiological genomics · 2021Article
- Empagliflozin Inhibits IL-1β-Mediated Inflammatory Response in Human Proximal Tubular Cells.International journal of molecular sciences · 2021Article
- Endothelin-targeted new treatments for proteinuric and inflammatory glomerular diseases: focus on the added value to anti-renin-angiotensin system inhibition.Pediatric nephrology (Berlin, Germany) · 2021Review
- Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells.International journal of molecular sciences · 2020Article
- NOX4-dependent regulation of ENaC in hypertension and diabetic kidney disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome.Biology of sex differences · 2020Article
- Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats.American journal of physiology. Renal physiology · 2020Article
- Targeting the progression of chronic kidney disease.Nature reviews. Nephrology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Denisha SpiresDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Bibek PoudelDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Corbin A ShieldsDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Alyssa PenningtonDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Brianca FizerDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Lateia TaylorDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Kasi C McPhersonDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Denise C CorneliusDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
Jan M WilliamsDepartments of Pharmacology and Emergency Medicine, University of Mississippi Medical Center , Jackson, Mississippi.
University of Mississippi Medical Center · US
Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2MThe role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2013 to 2022
$23.4MMechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7MHypertension and InflammationR00HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2017 to 2019
$747kHypertension and InflammationK99HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2016 to 2016
$136kThe role of ET-1 in lipid accumulation during the development of glomerular injury associated with MetSF31DK109571 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI MCPHERSON, KASI C · 2016 to 2016
$26kNHLBI NIH HHS K99 HL130456NHLBI NIH HHS R00 HL130456NIDDK NIH HHS F31 DK109571NIDDK NIH HHS R01 DK109133NIGMS NIH HHS P20 GM104357NIGMS NIH HHS U54 GM115428
Abstract
The endothelin (ET) system has emerged as a therapeutic target for the treatment of diabetic nephropathy (DN). The present study examined whether chronic endothelin A (ET
Indexed as
AnimalsBlood PressureDiabetes Mellitus, Type 2Diabetic NephropathiesEndothelin A Receptor AntagonistsHypertensionKidneyKidney GlomerulusMaleRatsReceptor, Endothelin ASodium Chloride, DietaryEndothelin A Receptor AntagonistsReceptor, Endothelin ASodium Chloride, DietaryatrasentanDahl S ratsdiabetic nephropathyrenal injuryTDN ratstype 1 and type 2 diabetes
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.