Evidence map›Paper›PMID 29846109›Full record

ArticleAmerican journal of physiology. Renal physiology2018

Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.

Hui Fang, Mokan Deng, Linlin Zhang, Aihua Lu, Jiahui Su, Chuanming Xu, Li Zhou, Lei Wang, Jing-Song Ou, Weidong Wang and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Therapeutic potential ofFrontiers in pharmacology · 2023
    Article
  5. Review
  6. Role of (pro)renin receptor in cyclosporin A-induced nephropathy.American journal of physiology. Renal physiology · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. (Pro)renin receptor in the kidney: function and significance.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. The (pro)renin receptor in health and disease.Nature reviews. Nephrology · 2019
    Review
  17. Article
  18. Article
  19. Soluble (pro)renin receptor as a potential therapy for diabetes insipidus.American journal of physiology. Renal physiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Hui FangInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Mokan DengInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Linlin ZhangInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Aihua LuInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Jiahui SuInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Chuanming XuInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Li ZhouInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Lei WangInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Jing-Song OuDivision of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou , China.
Weidong WangInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Tianxin YangInstitute of Hypertension, Sun Yat-sen University zhongshan School of Medicine , Guangzhou , China.
Sun Yat-sen University · CNUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteinuria is not only a common feature of chronic kidney diseases (CKD) but also an independent risk factor promoting CKD progression to end-stage renal failure. However, the underlying molecular mechanisms for protein overload-induced renal injury remain elusive. The present study examined the role of (pro)renin receptor (PRR) in pathogenesis of albumin overload (AO)-induced nephropathy and activation of the intrarenal renin-angiotensin system (RAS) in rats. Wistar rats underwent unilateral nephrectomy and were treated for 7 wk with vehicle, bovine serum albumin (5 g·kg

Indexed as

Renin-Angiotensin SystemSerum Albumin, BovineAnimalsDisease Models, AnimalFibrosisInflammation MediatorsKidneyKidney DiseasesMaleNephrectomyOxidative StressPeptide FragmentsProrenin ReceptorProteinuriaRats, WistarReceptors, Cell SurfaceATP6AP2 protein, ratInflammation MediatorsPeptide FragmentsPRO20 peptideProrenin ReceptorReceptors, Cell SurfaceReninSerum Albumin, BovineVacuolar Proton-Translocating ATPasesalbumin overloadchronic kidney diseasePRO20(pro)renin receptorproteinuriarenin-angiotensin system

Identifiers

PMID29846109
PMCPMC6336996
OpenAlexW2807141939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.