Evidence map›Paper›PMID 29846037›Full record

ArticleAngewandte Chemie (International ed. in English)2018

Stabilising Peptoid Helices Using Non-Chiral Fluoroalkyl Monomers.

Diana Gimenez, Juan A Aguilar, Elizabeth H C Bromley, Steven L Cobb

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. First series ofBeilstein journal of organic chemistry · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Stabilising Peptoid Helices Using Non-Chiral Fluoroalkyl Monomers.Angewandte Chemie (International ed. in English) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Diana GimenezDepartment of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
Juan A AguilarDepartment of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.
Elizabeth H C BromleyDepartment of Physics, Durham University, South Road, Durham, DH1 3LE, UK.
Steven L CobbDepartment of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.ORCID 0000-0002-3790-7023
Durham University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stability towards protease degradation combined with modular synthesis has made peptoids of considerable interest in the fields of chemical biology, medicine, and biomaterials. Given their tertiary amide backbone, peptoids lack the capacity to hydrogen-bond, and as such, controlling secondary structure can be challenging. The incorporation of bulky, charged, or chiral aromatic monomers can be used to control conformation but such building blocks limit applications in many areas. Through NMR and X-ray analysis we demonstrate that non-chiral neutral fluoroalkyl monomers can be used to influence the K

Indexed as

AmidesCircular DichroismCrystallography, X-RayFluorineKineticsMagnetic Resonance SpectroscopyPeptoidsProtein Conformation, alpha-HelicalStereoisomerismAmidesFluorinePeptoidsfluorineNMR spectroscopypeptidomimeticspeptoidssecondary structure

Identifiers

PMID29846037
PMCPMC6099454
OpenAlexW2805888342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.