ArticleEnvironmental toxicology and chemistry2018
The advantages of linear concentration-response curves for in vitro bioassays with environmental samples.
Article in Environmental toxicology and chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
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- "The Dose Makes the Poison": Relevance of Paracelsus's Principle for Modern Chemical Hazard Assessment with New Approach Methodologies.Environmental science & technology · 2026Article
- Effect-Based Assessment of the Quality and Potential Presence of Hazardous Chemical Pollutants in Drinking and Potable Water in Mexico City.ACS ES&T water · 2026Article
- Zebrafish as a translational filter for natural sleep modulators.Frontiers in nutrition · 2026Review
- Following the Mixtures of Organic Micropollutants withACS environmental Au · 2025Article
- Role of Suspended Particulate Matter for the Transport and Risks of Organic Micropollutant Mixtures in Rivers: A Comparison between Baseflow and High Discharge Conditions.Environmental science & technology · 2025Article
- Assessing Modes of Toxic Action of Organic Cations inChemical research in toxicology · 2025Article
- Cytotoxicity and Oxidative Stress Induced by Technology-Critical ElementsEnvironmental science & technology · 2025Article
- Gaining confidence inNAM journal · 2025Article
- Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations.Environmental science & technology · 2024Article
- In Vitro Metabolism and p53 Activation of Genotoxic Chemicals: Abiotic CYP Enzyme vs Liver Microsomes.Chemical research in toxicology · 2024Article
- Extrapolation of cytotoxic masked effects in planar in vitro assays.Analytical and bioanalytical chemistry · 2024Article
- Effects of Chemicals in Reporter Gene Bioassays with Different Metabolic Activities Compared to Baseline Toxicity.Chemical research in toxicology · 2024Article
- Water Quality Monitoring with the Multiplexed Assay MitoOxTox for Mitochondrial Toxicity, Oxidative Stress Response, and Cytotoxicity in AREc32 Cells.Environmental science & technology · 2024Article
- Baseline Toxicity Model to Identify the Specific and Nonspecific Effects of Per- and Polyfluoroalkyl Substances in Cell-Based Bioassays.Environmental science & technology · 2024Article
- In vitro bioassays for monitoring drinking water quality of tap water, domestic filtration and bottled water.Journal of exposure science & environmental epidemiology · 2024Article
- Predicted versus observed activity of PCB mixtures toward the ryanodine receptor.Neurotoxicology · 2024Article
- Review
- Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response.Chemical research in toxicology · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In vitro assays and high-throughput screening (HTS) tools are increasingly being employed as replacements for animal testing, but most concentration-response curves are still evaluated with models developed for animal testing. We argue that application of in vitro assays, particularly reporter gene assays, to environmental samples can benefit from a different approach to concentration-response modeling. First, cytotoxicity often occurs at higher concentrations, especially for weakly acting compounds and in complex environmental mixtures with many components. In these cases, specific effects can be masked by cytotoxicity. Second, for many HTS assays, low effect levels can be precisely quantified because of the low variability of controls in cell-based assays and the opportunity to run many concentrations and replicates when using high-density well-plate formats (e.g., 384 or more wells per plate). Hence, we recommend focusing concentration-response modeling on the lower portion of the concentration-response curve, which is approximately linear. Effect concentrations derived from low-effect level linear concentration-response models facilitate simple derivation of relative effect potencies and the correct application of mixture toxicity models in the calculation of bioanalytical equivalent concentrations. Environ Toxicol Chem 2018;37:2273-2280. © 2018 SETAC.
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