ArticlePhysiological reports2018
Modelling the effect of gravity on inert-gas washout outputs.
Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Investigation of inert gas washout methods in a new numerical model based on an electrical analogy.Medical & biological engineering & computing · 2025Article
- Ventilation heterogeneity imaged by multibreath wash-ins of hyperpolarizedThe Journal of physiology · 2021Article
- Image-based simulation and modeling: unlocking small airway function tests?Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Proning reduces ventilation heterogeneity in patients with elevated BMI: implications for COVID-19 pneumonia management?ERJ open research · 2020Article
- Modelling the effect of gravity on inert-gas washout outputs.Physiological reports · 2018Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple-breath washout (MBW) is a pulmonary function test (PFT) that is used to infer lung function through measurement of ventilation heterogeneity (VH). However, the body position that a test is taken in may also influence VH, due to the "Slinky" effect of gravity on the lungs. In healthy subjects this has minimal effect, but in unhealthy groups, PFT outputs have been seen to change drastically with body position. In this study, we used a combined computational and clinical approach to better understand the response of outputs from the MBW to body position. A patient-specific model of the MBW was developed, then validated against clinically measured washout data, as well as broader results in the literature. This model was then used to compare changes in MBW outputs with respect to body position, showing that output changes sensitively predict regional airway size differences between lobes. We then highlight cases in which body position effects may bias MBW outputs, leading to elevated or masked responses to bronchoconstriction. We close by placing this result in context with broader clinical practice, and showing how it can help improve interpretation of test outputs.
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Registered trials
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