ArticleAngewandte Chemie (International ed. in English)2018
Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Access to Pyrazolo[1,5-Organic letters · 2026Article
- The Pan-Canadian Chemical Library: A Mechanism to Open Academic Chemistry to High-Throughput Virtual Screening.Scientific data · 2024Article
- Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity.Bioorganic & medicinal chemistry letters · 2024Article
- β-Lactams from the Ocean.Marine drugs · 2023Review
- Article
- A Novel Nano-Antimicrobial Polymer Engineered with Chitosan Nanoparticles and Bioactive Peptides as Promising Food Biopreservative Effective against Foodborne PathogenInternational journal of molecular sciences · 2021Article
- Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence.Accounts of chemical research · 2021Article
- Genetic Determinants ofApplied and environmental microbiology · 2020Article
- 5-Benzylidene-4-Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms.Chembiochem : a European journal of chemical biology · 2020Article
- Expanded Structure-Activity Studies of Lipoxazolidinone Antibiotics.ACS medicinal chemistry letters · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Natural products have historically been a major source of antibiotics and therefore novel scaffolds are constantly of interest. The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogues to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.
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