Evidence map›Paper›PMID 29845478›Full record

ArticleHead and neck pathology2019

P53 Gene Mutation Identified by Next Generation Sequencing in Poorly Differentiated Neuroendocrine Carcinoma of the Nasal Cavity.

Jason K Wasserman, Doaa AlGhamdi, John R de Almeida, Tracy L Stockley, Bayardo Perez-Ordonez

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jason K WassermanLaboratory Medicine Program, University Health Network, Toronto, ON, Canada. bayardo.perez-ordonez@uhn.ca.
Doaa AlGhamdiLaboratory Medicine Program, University Health Network, Toronto, ON, Canada.
John R de AlmeidaDepartment of Otolaryngology Head and Neck Surgery, Department of Surgical Oncology, University Health Network, Toronto, ON, Canada.
Tracy L StockleyLaboratory Medicine Program, University Health Network, Toronto, ON, Canada.
Bayardo Perez-OrdonezLaboratory Medicine Program, University Health Network, Toronto, ON, Canada.
University Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine carcinomas (NECs) are epithelial neoplasms showing morphologic, immunophenotypic or ultrastructural evidence of neuroendocrine differentiation. The 2017 WHO Classification of Head and Neck Tumours classifies NECs into well, moderately and poorly differentiated NECs according to light microscopic features, mitotic rate and presence of tumour necrosis. In this study, we performed next generation sequencing (NGS) using a targeted 161 cancer gene panel on a poorly differentiated NEC of the nasal cavity. The tumour was composed of large cells arranged in poorly formed glands and solid nests. The mitotic count rate was 30/10 HPFs and p53 protein was strongly expressed in all tumour cells. NGS identified a missense mutation, c.764T > G (p.Ile255Ser) in the TP53 gene with an allele frequency of 85%. This mutation results in an isoleucine to serine substitution and a non-functional protein. No other mutations were identified. These results suggest that TP53 mutations may drive oncogenesis in poorly differentiated NECs of the head and neck.

Indexed as

Carcinoma, NeuroendocrineFemaleHigh-Throughput Nucleotide SequencingHumansMiddle AgedMutation, MissenseNasal CavityNose NeoplasmsTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53Head and neckNasal cavityNeuroendocrine carcinomaNext-generation sequencingTP53 mutation

Identifiers

PMID29845478
PMCPMC6684699
OpenAlexW2806301076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.