Evidence map›Paper›PMID 29845425›Full record

ArticleMolecular imaging and biology2019

A Novel PET Probe "[

Yoichi Shimizu, Songji Zhao, Hironobu Yasui, Ken-Ichi Nishijima, Hiroki Matsumoto, Tohru Shiga, Nagara Tamaki, Mikako Ogawa, Yuji Kuge

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Review
  4. JACS Au · 2024
    Article
  5. In vivo stableEJNMMI radiopharmacy and chemistry · 2024
    Article
  6. Article
  7. Article
  8. Eribulin improves tumor oxygenation demonstrated byEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  9. Increased [EJNMMI research · 2021
    Article
  10. RepurposingTheranostics · 2021
    Article
  11. The Roles of Hypoxia Imaging UsingJournal of clinical medicine · 2019
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yoichi ShimizuLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan. yshimizu@pharm.hokudai.ac.jp.ORCID http://orcid.org/0000-0002-6629-1352
Songji ZhaoGraduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
Hironobu YasuiCentral Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Ken-Ichi NishijimaCentral Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Hiroki MatsumotoResearch Centre, Nihon Medi-Physics Co., Ltd., 3-1 Kitatode, Sodegaura, Chiba, 299-0266, Japan.
Tohru ShigaGraduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
Nagara TamakiGraduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.
Mikako OgawaLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan.
Yuji KugeCentral Institute of Isotope Science, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-0815, Japan.
Hokkaido University · JPNihon Medi-Physics (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHypoxia in tumor has close relationship with angiogenesis and tumor progression. Previously, we developed 2,2-dihydroxymethyl-3-[ PROCEDURES: FaDu human head and neck cancer cells were treated with [

resultsIn the in vitro study, the radioactivity of FaDu cells was significantly higher under hypoxia than that under normoxia (0.53 ± 0.02 vs. 0.27 ± 0.02 %dose/mg protein, p < 0.05). The radioactivity of the low-molecular-weight fraction was 66.3 ± 0.6% in the hypoxic cell. In the in vivo study, [

conclusionsOur results suggest that [

Indexed as

Fluorine RadioisotopesTumor HypoxiaAnimalsGlutathioneHead and Neck NeoplasmsHeterograftsHumansHypoxiaMaleMiceMice, Inbred BALB CMice, NudeNitroimidazolesOxidation-ReductionOxidative StressPositron-Emission TomographyFluorine-18Fluorine RadioisotopesGlutathioneNitroimidazolesDiFAGlutathioneHypoxiaImaging mass spectrometryMolecular imaging

Identifiers

PMID29845425
OpenAlexW2806606560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.