ArticleAnalytical and bioanalytical chemistry2018
Analysis of lipid adsorption on nanoparticles by nanoflow liquid chromatography-tandem mass spectrometry.
Article in Analytical and bioanalytical chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome.Nature reviews. Clinical oncology · 2022Review
- Influence of surface chemistry and morphology of nanoparticles on protein corona formation.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022Review
- Understanding the Significance of Sample Preparation in Studies of the Nanoparticle Metabolite Corona.ACS measurement science au · 2022Article
- Metal Oxide Engineered Nanomaterials Modulate Rabbit Corneal Fibroblast to Myofibroblast Transformation.Translational vision science & technology · 2021Article
- Delivery of Oligonucleotide Therapeutics: Chemical Modifications, Lipid Nanoparticles, and Extracellular Vesicles.ACS nano · 2021Review
- Formation of a protein corona on the surface of extracellular vesicles in blood plasma.Journal of extracellular vesicles · 2021Article
- Environmental dimensions of the protein corona.Nature nanotechnology · 2021Review
- Effects of Ingested Nanomaterials on Tissue Distribution of Co-ingested Zinc and Iron in Normal and Zinc-Deficient Mice.NanoImpact · 2021Article
- Lipid and protein corona of food-grade TiONanoImpact · 2020Article
- Toxicity assessment of metal oxide nanomaterials usingNanoImpact · 2020Article
- Engineering Two-dimensional Nanomaterials to Enable Structure-Activity Relationship Studies in Nanosafety Research.NanoImpact · 2020Article
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- Mapping 2D- and 3D-distributions of metal/metal oxide nanoparticles within cleared humanNanoImpact · 2020Article
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- Best practice in reporting corona studies: Minimum information about Nanomaterial Biocorona Experiments (MINBE).Nano today · 2019Article
- Co-exposure to the food additives SiOEnvironmental science. Nano · 2019Article
- Toxicological effects of ingested nanocellulose in in vitro intestinal epithelium and in vivo rat models.Environmental science. Nano · 2019Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Nanoparticles (NPs) tend to adsorb matrix molecules like proteins and lipids incubated with biological fluids, forming a biological corona. While the formation and functions of protein corona have been studied extensively, little attention has been paid to lipid adsorption on NPs. However, lipids are also abundantly present in biological fluids and play important roles in processes like cell signaling and angiogenesis. Therefore, in this study, we established the analytical procedure for study of lipid adsorption on three different types of NPs in two matrices: human serum and heavy cream, using nanoflow liquid chromatography-mass spectrometry (nanoflowLC-MS). Serum was chosen to represent the common environment the NPs would be present once entering human body, and heavy cream was the representative food matrix NPs may be added to improve the color or taste. Steps of liquid-liquid extraction were established and optimized to achieve maximum recovery of the adsorbed, standard lipids from the NPs. Then, the LC-MS/MS method was developed to attain base-line separation of the standard lipids that represent the major lipid classes. At last, the lipid adsorption profiles of the three NPs were compared. We found that the lipid adsorption profile on the same type of NP was significantly different between the two matrices. The established method will help us investigate lipid adsorption on additional NPs and reveal how it could be affected by the physiochemical properties of NPs and the presence of proteins and other components in the biological matrix.
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