Evidence map›Paper›PMID 29845318›Full record

ArticleInvertebrate neuroscience : IN2018

egl-4 modulates electroconvulsive seizure duration in C. elegans.

Monica G Risley, Stephanie P Kelly, Justin Minnerly, Kailiang Jia, Ken Dawson-Scully

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Invertebrate neuroscience : IN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Monica G RisleyDepartment of Biological Sciences, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Stephanie P KellyDepartment of Biological Sciences, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Justin MinnerlyDepartment of Biological Sciences, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Kailiang JiaDepartment of Biological Sciences, Florida Atlantic University, Boca Raton, FL, 33431, USA.
Ken Dawson-ScullyDepartment of Biological Sciences, Florida Atlantic University, Boca Raton, FL, 33431, USA. ken.dawson-scully@fau.edu.
Florida Atlantic University · USMax Planck Florida Institute for Neuroscience · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
The novel role of autophagy in controlling C. elegans dauer recoveryR15HD080497 · NICHD · FLORIDA ATLANTIC UNIVERSITY · PI JIA, KAILIANG · 2014 to 2014
$357k
NICHD NIH HHS R15 HD080497NIH HHS P40 OD010440
6 · The paper itself

Abstract

Increased neuronal excitability causes seizures with debilitating symptoms. Effective and noninvasive treatments are limited for easing symptoms, partially due to the complexity of the disorder and lack of knowledge of specific molecular faults. An unexplored, novel target for seizure therapeutics is the cGMP/protein kinase G (PKG) pathway, which targets downstream K

Indexed as

AnimalsAnticonvulsantsCaenorhabditis elegansCaenorhabditis elegans ProteinsCarbamatesCyclic GMPCyclic GMP-Dependent Protein KinasesDisease Models, AnimalElectroshockPhenylenediaminesRecovery of FunctionSeizuresSignal Transduction8-bromocyclic GMPAnticonvulsantsCaenorhabditis elegans ProteinsCarbamatesCyclic GMPCyclic GMP-Dependent Protein KinasesEGL-4 protein, C elegansezogabinePhenylenediaminesC. elegansElectroconvulsive seizureEpilepsyPKGProtein kinase GSeizure

Identifiers

PMID29845318
PMCPMC6233307
OpenAlexW2805696193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.