Evidence map›Paper›PMID 29845108›Full record

ArticleNPJ Parkinson's disease2018

Changes in Parkinson's disease sleep symptoms and daytime somnolence after bilateral subthalamic deep brain stimulation in Parkinson's disease.

Siddharth Kharkar, Jonathan Richard Ellenbogen, Michael Samuel, Alexandra Rizos, Monty Silverdale, K Ray Chaudhuri, Keyoumars Ashkan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Siddharth Kharkar1Department of Neurology, Wockhardt Hospitals, Mumbai, Maharashtra India.
Jonathan Richard Ellenbogen2Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Michael Samuel3Department of Neurology, King's College Hospital NHS Foundation Trust, London, UK.
Alexandra Rizos4EUROPAR Offices, King's College Hospital NHS Foundation Trust, London, UK.
Monty Silverdale5Department of Neurology, Salford Royal NHS Foundation Trust, Manchester, UK.
K Ray Chaudhuri *3Department of Neurology, King's College Hospital NHS Foundation Trust, London, UK.
Keyoumars Ashkan *2Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
King's College Hospital NHS Foundation Trust · GBSalford Royal NHS Foundation Trust · GBWockhardt Hospitals · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDeep brain stimulation (DBS) markedly improves motor function in advanced Parkinson's disease (PD), but its effect on sleep is less clear. PATIENTS AND

methodsForty PD patients who had subthalamic DBS (STN-DBS) were identified from an on-going non-motor naturalistic longitudinal study (NILS). All patients were followed up for at least 6 months, 26 patients had a 1 year follow-up. A total PDSS score of 100 or less, a score in any PDSS-item of 6 or less, and a Epworth score of 10 or more were classified as being significant.

resultsForty-five percent of patients reported significant improvement in the total PDSS score at 6 months, and 35% at 12 months. In terms of magnitude, the total PDSS score at 6 months was significantly improved from baseline while the improvement at 12 months was not statistically significant. The most frequently reported improvements were overall sleep quality and maintenance of sleep. Some patients reported worsening of the total PDSS score. More than half of the patients reporting daytime sleepiness at baseline had persistent sleepiness at 6 and 12 months. The mean Epworth Score did not improve because a significant number of patients

conclusionSubthalamic DBS is associated with a statistically and clinically significant, but variable, improvement in sleep as measured by the PDSS. The most frequent improvements were better overall sleep quality and better sleep maintenance.

Identifiers

PMID29845108
PMCPMC5970229
OpenAlexW2803112178

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.