ArticleNeuroImage. Clinical2018
Connectivity-enhanced diffusion analysis reveals white matter density disruptions in first episode and chronic schizophrenia.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Long-term cognitive training enhances fluid cognition and brain connectivity in individuals with MCI.Translational psychiatry · 2024Trial
- Widespread white matter microstructural abnormalities in treatment‑naïve patients with first‑episode schizophrenia revealed by fixel-based analysis.Translational psychiatry · 2026Article
- Psychotic-Like Experiences and White Matter Microstructure: A Fixel-Based Analysis Approach With Robust Replication Across Two Cohorts.Human brain mapping · 2025Article
- Utility of Harmonisation for Fixel-Based Metrics in Travelling Subjects and Alzheimer's Disease Data.Human brain mapping · 2025Article
- Graph Neural Networks and Multimodal DTI Features for Schizophrenia Classification: Insights from Brain Network Analysis and Gene Expression.Neuroscience bulletin · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis.Translational psychiatry · 2024Article
- Fibre density and fibre-bundle cross-section of the corticospinal tract are distinctly linked to psychosis-specific symptoms in antipsychotic-naïve patients with first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury.Scientific reports · 2023Article
- Article
- Symptoms reported by Canadians posted in Havana are linked with reduced white matter fibre density.Brain communications · 2022Article
- Age-Related Differences in White Matter: Understanding Tensor-Based Results Using Fixel-Based Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Visual Dysfunction Predicts Cognitive Impairment and White Matter Degeneration in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome.Neuroradiology · 2021Article
- Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury.Frontiers in neuroscience · 2021Article
- Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.Schizophrenia research · 2020Article
- Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Fiber-specific white matter reductions in Parkinson hallucinations and visual dysfunction.Neurology · 2020Article
- Discriminating VCID subgroups: A diffusion MRI multi-model fusion approach.Journal of neuroscience methods · 2020Review
- Dementia risk in Parkinson's disease is associated with interhemispheric connectivity loss and determined by regional gene expression.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Reduced fractional anisotropy (FA) is a well-established correlate of schizophrenia, but it remains unclear whether these tensor-based differences are the result of axon damage and/or organizational changes and whether the changes are progressive in the adult course of illness. Diffusion MRI data were collected in 81 schizophrenia patients (54 first episode and 27 chronic) and 64 controls. Analysis of FA was combined with "fixel-based" analysis, the latter of which leverages connectivity and crossing-fiber information to assess both fiber bundle density and organizational complexity (i.e., presence and magnitude of off-axis diffusion signal). Compared with controls, patients with schizophrenia displayed clusters of significantly lower FA in the bilateral frontal lobes, right dorsal centrum semiovale, and the left anterior limb of the internal capsule. All FA-based group differences overlapped substantially with regions containing complex fiber architecture. FA within these clusters was positively correlated with principal axis fiber density, but inversely correlated with both secondary/tertiary axis fiber density and voxel-wise fiber complexity. Crossing fiber complexity had the strongest (inverse) association with FA (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.