Evidence map›Paper›PMID 29845008›Full record

ArticleNeuroImage. Clinical2018

Locally stable brain states predict suppression of epileptic activity by enhanced cognitive effort.

Sarah F Muldoon, Julia Costantini, W R S Webber, Ronald Lesser, Danielle S Bassett

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarah F MuldoonDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; US Army Research Laboratory, Aberdeen, MD 21005, USA.
Julia CostantiniDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
W R S WebberJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ronald LesserJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Danielle S BassettDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Physics & Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dsb@seas.upenn.edu.

Funding

Linguistic and NonLinguistic Functions of Frontal CortexR01DC009209 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI THOMPSONSCHILL, SHARON L · 2008 to 2018
$5.2M
Longitudinal multi-modal neuroimaging of irritability in youthR01MH107703 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SATTERTHWAITE, THEODORE · 2015 to 2018
$2.6M
Virtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3M
Brain Network Mechanisms of Instructed LearningR01MH109520 · NIMH · RUTGERS THE STATE UNIV OF NJ NEWARK · PI COLE, MICHAEL WILLIAM · 2016 to 2020
$2.0M
Multimodal brain maturation indices modulating psychopathology and neurocognitionR01MH107235 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RUBEN C. · 2015 to 2017
$1.5M
Evolution of the Linked Architecture of Network Control and Executive Function in AdolescenceR21MH106799 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, SATTERTHWAITE, THEODORE · 2016 to 2017
$515k
CRCNS: US-France Modeling & Predicting BCI Learning from Dynamic NetworksR01HD086888 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH · 2015 to 2018
$506k
NICHD NIH HHS R01 HD086888NIDCD NIH HHS R01 DC009209NIMH NIH HHS R01 MH107235NIMH NIH HHS R01 MH107703NIMH NIH HHS R01 MH109520NIMH NIH HHS R21 MH106799NINDS NIH HHS R01 NS099348
6 · The paper itself

Abstract

Cognitive effort is known to play a role in healthy brain state organization, but little is known about its effects on pathological brain dynamics. When cortical stimulation is used to map functional brain areas prior to surgery, a common unwanted side effect is the appearance of afterdischarges (ADs), epileptiform and potentially epileptogenic discharges that can progress to a clinical seizure. It is therefore desirable to suppress this activity. Here, we analyze electrocorticography recordings from 15 patients with epilepsy. We show that a cognitive intervention in the form of asking an arithmetic question can be effective in suppressing ADs, but that its effectiveness is dependent upon the brain state at the time of intervention. By applying novel techniques from network analysis to quantify brain states, we find that the spatial organization of ADs with respect to coherent brain regions relates to the success of the cognitive intervention: if ADs are mainly localized within a single stable brain region, a cognitive intervention is likely to suppress the ADs. These findings show that cognitive effort is a useful tactic to modify unstable pathological activity associated with epilepsy, and suggest that the success of therapeutic interventions to alter activity may depend on an individual's brain state at the time of intervention.

Indexed as

AdolescentAdultBrainBrain MappingChildCognitionElectrocorticographyEpilepsyFemaleHumansMaleMiddle AgedNerve NetSeizuresYoung AdultAD, afterdischargeAfterdischargesBPS, brief pulse stimulationBrain networksCognitive interventionECoG, electrocorticographyEpilepsyFunctional connectivity

Identifiers

PMID29845008
PMCPMC5964828

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.