Evidence map›Paper›PMID 29845006›Full record

ArticleNeuroImage. Clinical2018

Decreased functional connectivity in the fronto-parietal network in children with mood disorders compared to children with dyslexia during rest: An fMRI study.

Tzipi Horowitz-Kraus, Mackenzie Woodburn, Akila Rajagopal, Amelia L Versace, Robert A Kowatch, Michele A Bertocci, Genna Bebko, Jorge R C Almeida, Susan B Perlman, Michael J Travis and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 9 institutions in 2 countries.

Tzipi Horowitz-KrausCincinnati Children's Hospital Medical Center, University of Cincinnati, United States; Educational Neuroimaging Center, Faculty of Education in Science and Technology, Technion, Israel. Electronic address: Tzipi.Kraus@technion.ac.il.
Mackenzie WoodburnCincinnati Children's Hospital Medical Center, University of Cincinnati, United States.
Akila RajagopalDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Amelia L VersaceDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Robert A KowatchThe Research Institute at Nationwide Children's Hospital, United States; Department of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States.
Michele A BertocciDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Genna BebkoDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Jorge R C AlmeidaDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Susan B PerlmanDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Michael J TravisDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Mary Kay GillDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Lisa BonarDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Claudiu SchirdaDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Vaibhav A DiwadkarDepartment of Psychiatry and Behavioral Neuroscience, Wayne State University, United States.
Jeffrey L SunshineDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Boris BirmaherDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
David AxelsonDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States.
H Gerry TaylorUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, United States.
Sarah M HorwitzDepartment of Child Psychiatry, New York University School of Medicine, United States.
Thomas FrazierDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States.
L Eugene ArnoldDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States.
Mary A FristadDepartment of Psychiatry and Behavioral Health, Wexner Medical Center, Ohio State University, United States.
Eric A YoungstromDepartment of Psychology, University of North Carolina at Chapel Hill, United States.
Robert L FindlingUniversity Hospitals Cleveland Medical Center, Case Western Reserve University, United States; Department of Psychiatry, Johns Hopkins University, United States.
Mary L PhillipsDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, United States.
Scott K HollandCincinnati Children's Hospital Medical Center, University of Cincinnati, United States.
University of Pittsburgh Medical Center · USCincinnati Children's Hospital Medical Center · USThe Ohio State University Wexner Medical Center · USUniversity Hospitals of Cleveland · USJohns Hopkins University · USNationwide Children's Hospital · USNew York University · USUniversity of North Carolina at Chapel Hill · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The DSM-5 separates the diagnostic criteria for mood and behavioral disorders. Both types of disorders share neurocognitive deficits of executive function and reading difficulties in childhood. Children with dyslexia also have executive function deficits, revealing a role of executive function circuitry in reading. The aim of the current study is to determine whether there is a significant relationship of functional connectivity within the fronto-parietal and cingulo-opercular cognitive control networks to reading measures for children with mood disorders, behavioral disorders, dyslexia, and healthy controls (HC). Method: Behavioral reading measures of phonological awareness, decoding, and orthography were collected. Resting state fMRI data were collected, preprocessed, and then analyzed for functional connectivity. Differences in the reading measures were tested for significance among the groups. Global efficiency (GE) measures were also tested for correlation with reading measures in 40 children with various disorders and 17 HCs. Results: Significant differences were found between the four groups on all reading measures. Relative to HCs and children with mood disorders or behavior disorders, children with dyslexia as a primary diagnosis scored significantly lower on all three reading measures. Children with mood disorders scored significantly lower than controls on a test of phonological awareness. Phonological awareness deficits correlated with reduced resting state functional connectivity MRI (rsfcMRI) in the cingulo-opercular network for children with dyslexia. A significant difference was also found in fronto-parietal global efficiency in children with mood disorders relative to the other three groups. We also found a significant difference in cingulo-opercular global efficiency in children with mood disorders relative to the Dyslexia and Control groups. However, none of these differences correlate significantly with reading measures. Conclusions/significance: Reading difficulties involve abnormalities in different cognitive control networks in children with dyslexia compared to children with mood disorders. Findings of the current study suggest increased functional connectivity of one cognitive control network may compensate for reduced functional connectivity in the other network in children with mood disorders. These findings provide guidance to clinical professionals for design of interventions tailored for children suffering from reading difficulties originating from different pathologies.

Indexed as

AdolescentBrain MappingChildDyslexiaExecutive FunctionFemaleFrontal LobeFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMood DisordersNerve NetNeuropsychological TestsParietal LobeReadingBehavioral disordersDyslexiaExecutive function networksMood disordersPhonological awarenessReadingResting state functional connectivity

Identifiers

PMID29845006
PMCPMC5964829
OpenAlexW2793300658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.