Evidence map›Paper›PMID 29844968›Full record

ArticlePeerJ2018

High correlation between skin color based on CIELAB color space, epidermal melanocyte ratio, and melanocyte melanin content.

Wen-Shyan Huang, Yi-Wen Wang, Kun-Che Hung, Pai-Shan Hsieh, Keng-Yen Fu, Lien-Guo Dai, Nien-Hsien Liou, Kuo-Hsing Ma, Jiang-Chuan Liu, Niann-Tzyy Dai

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Antera 3DArchives of dermatological research · 2025
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  5. Blue light protection factor: a method to assess the protective efficacy of cosmetics against blue light-induced skin damage in the Chinese population.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
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  6. Exploratory study on the body distribution of skin color, pigmentation and, degree of tan in Central European Caucasian Women.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Article
  7. Article
  8. Article
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  10. Evaluation of a simple image-based tool to quantify facial erythema in rosacea during treatment.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2020
    Article
  11. Article
  12. Immunoactivation Affects Perceived Body Odor and Facial but Not Vocal Attractiveness.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wen-Shyan Huang *Division of Plastic and Reconstructive Surgery, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.
Yi-Wen Wang *Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Kun-Che HungDivision of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Pai-Shan HsiehDivision of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Keng-Yen FuDivision of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Lien-Guo DaiDepartment of Orthopedics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, R.O.C.
Nien-Hsien LiouDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Kuo-Hsing MaDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Jiang-Chuan LiuDepartment of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Niann-Tzyy DaiDivision of Plastic and Reconstructive Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.
National Defense Medical Center · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo treat skin color disorders, such as vitiligo or burns, melanocytes are transplanted for tissue regeneration. However, melanocyte distribution in the human body varies with age and location, making it difficult to select the optimal donor skin to achieve a desired color match. Determining the correlations with the desired skin color measurement based on CIELAB color, epidermal melanocyte numbers, and melanin content of individual melanocytes is critical for clinical application.

methodFifteen foreskin samples from Asian young adults were analyzed for skin color, melanocyte ratio (melanocyte proportion in the epidermis), and melanin concentration. Furthermore, an equation was developed based on CIELAB color with melanocyte ratio, melanin concentration, and the product of melanocyte ratio and melanin concentration. The equation was validated by seeding different ratios of keratinocytes and melanocytes in tissue-engineered skin substitutes, and the degree of fitness in expected skin color was confirmed.

resultsLinear regression analysis revealed a significant strong negative correlation ( DISCUSSION: We found that

Indexed as

CIELAB color spaceColor readerHypopigmentationPigment cellSkin tissue engineering

Identifiers

PMID29844968
PMCPMC5971097
OpenAlexW2803293646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.