ArticlePeerJ2018
Potentially inappropriate use of benzodiazepines and z-drugs in the older population-analysis of associations between long-term use and patient-related factors.
Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Reducing prescribing of benzodiazepines in older adults: a comparison of four physician-focused interventions by a medical regulatory authority.BMC family practice · 2021Trial
- Development of a Women's Empowerment Nurse-Led Group Intervention for Benzodiazepine and Z-Hypnotic Deprescription in Primary Healthcare: Results of a Co-Creation Process.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Prescription duration of benzodiazepines: a retrospective cohort study of prescription duration in primary care.European journal of clinical pharmacology · 2026Article
- Sleep status among adults.Sleep & breathing = Schlaf & Atmung · 2026Article
- Lifetime burden of prescription medication for insomnia in middle-aged and older adults in the US: a microsimulation study.Lancet regional health. Americas · 2025Article
- Off-Label Prescription of Benzodiazepines: A Retrospective Cohort Study of Prescribing Prevalence in Primary Care.Clinical drug investigation · 2025Article
- Medication patterns and potentially inappropriate medication in patients with metastatic breast cancer: results of the BRE-BY-MED study.BMC cancer · 2025Article
- Psychosocial characteristics of the general population who habitually use hypnotics: Results from a national survey on drug use among the Japanese.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Genetics of sleep medication purchases suggests causality from sleep problems to psychiatric traits.Sleep · 2024Article
- Long-term benzodiazepine prescriptions in community psychiatry clinics.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Effects on Sleep Quality of Physical Exercise Programs in Older Adults: A Systematic Review and Meta-Analysis.Clocks & sleep · 2023Review
- Chronic Insomnia Disorder across Europe: Expert Opinion on Challenges and Opportunities to Improve Care.Healthcare (Basel, Switzerland) · 2023Review
- Mapping the insomnia patient journey in Europe and Canada.Frontiers in public health · 2023Article
- Falls, healthcare resources and costs in older adults with insomnia treated with zolpidem, trazodone, or benzodiazepines.BMC geriatrics · 2022Article
- Factors Associated with Benzodiazepines Prolonged-Term Use in Post-Stroke Subjective Sleep Disturbance: A Single-Centre Retrospective Study from China.Drug design, development and therapy · 2021Article
- Patterns of Benzodiazepine Use and Excess Risk of All-Cause Mortality in the Elderly: A Nationwide Cohort Study.Drug safety · 2021Article
- Patterns of benzodiazepine prescription among older adults in Switzerland: a cross-sectional analysis of claims data.BMJ open · 2020Article
- Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe long-term use of benzodiazepines (BZD) and z-drugs in older populations is associated with a variety of sociodemographic and health-related factors. Recent studies reported that long-term BZD and z-drugs use is associated with increased age, female sex, and severe negative psychological (e.g., depression) and somatic (e.g., chronic disease) factors. The current study explores the sociodemographic and health-related factors associated with long-term BZD and z-drugs use in the elderly.
methodsWe conducted a cross-sectional survey among randomly selected patients of one health insurance plan ("AOK North-West") with BZD and z-drugs prescriptions in the past 12 months. The sample was stratified by appropriate German prescription guidelines (yes vs. no) and age (50-65 vs. >65 years). To examine the association of selected sociodemographic and psychological variables (e.g., sex, employment status, quality of life, depression) with long-term use, a binary logistic regression analysis was conducted.
resultsIn total, data from 340 patients were analyzed. The mean age was 72.1 ( DISCUSSION: Unemployment status and problematic medication use had a significant association with the patient-reported, long-term use of BZD and z-drugs. Divergent prescription patterns might suggest problematic patterns of BZD and z-drugs use. The causal connection between the identified factors and problematic BZD and z-drugs prescription is not discussed in this paper. Nevertheless, employment status and possible evidence of general problematic drug use may be a warning signal to the prescribers of BZD and z-drugs.
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