Evidence map›Paper›PMID 29844591›Full record

ArticleCellular & molecular immunology2019

Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis.

Weijun Wu, Ming Qin, Wanwan Jia, Zheng Huang, Zhongzheng Li, Di Yang, Mengwei Huang, Chenxi Xiao, Fen Long, Jianchun Mao and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 82 citations in OpenAlex.

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  18. Innate immune memory in inflammatory arthritis.Nature reviews. Rheumatology · 2023
    Review
  19. JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Weijun WuDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Ming QinDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Wanwan JiaDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Zheng HuangInstitute of Arthritis Research, Shanghai Academy of Chinese Medical Sciences, Guanghua Integrative Medicine Hospital/Shanghai University of T.C.M, Shanghai, China.
Zhongzheng LiNingbo The 9th Hospital, Ningbo, 315000, China.
Di YangDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Mengwei HuangDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Chenxi XiaoDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Fen LongDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China.
Jianchun MaoDepartment of Rheumatology, Shanghai Longhua Hospital, Shanghai, China.
Philip K MooreDepartment of Pharmacology, National University of Singapore, Singapore, Singapore.
Xinhua LiuDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China. liuxinhua@fudan.edu.cn.
Yi Zhun ZhuDepartment of Pharmacology, Shanghai Key Laboratory of Bioactive Small Molecules, School of Pharmacy, Fudan University, Shanghai, 201203, China. yzzhu@must.edu.mo.
Fudan University · CNMacau University of Science and Technology · MONational University of Singapore · SGNingbo No.6 Hospital · CNShanghai University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystathionine-γ-lyase (CSE), an enzyme associated with hydrogen sulfide (H

Indexed as

AnimalsArthritis, ExperimentalArthritis, RheumatoidAutoimmunityBenzazepinesCell LineCystathionine gamma-LyaseFibroblastsGene Knockout TechniquesHumansInflammationInterleukin-1betaJumonji Domain-Containing Histone DemethylasesMaleMiceMice, Inbred C57BLBenzazepinesCystathionine gamma-LyaseGSK-J4IL1B protein, humanInterleukin-1betaJumonji Domain-Containing Histone DemethylasesKDM6B protein, humanKdm6b protein, mousePyrimidinescystathionine-γ-lyaseJumonji domain-containing protein 3rheumatoid arthritisSp-1Toll like receptor 2

Identifiers

PMID29844591
PMCPMC6804949
OpenAlexW2807661191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.