ArticleScientific reports2018
Local field potential decoding of the onset and intensity of acute pain in rats.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Neuromodulation of the central nervous system for facial pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Pooled it
- Emergency Nurses' Perceptions and Experiences in Managing Acute Pain in Critically Ill Adult Patients: A Qualitative Study.Journal of advanced nursing · 2026Article
- Review
- RpiBeh offers a versatile open source solution for rodent behavior tracking and closed loop interventions.Scientific reports · 2025Article
- Establishing an Electrophysiological Recording Platform for Epidural Spinal Cord Stimulation in Neuropathic Pain Rats.Journal of pain research · 2025Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex.Molecular brain · 2023Article
- Interhemispheric neural characteristics of noxious mechano-nociceptive stimulation in the anterior cingulate cortex.Frontiers in neural circuits · 2023Article
- Closed-loop stimulation using a multiregion brain-machine interface has analgesic effects in rodents.Science translational medicine · 2022Article
- Role of CXCL10 in Spinal Cord Injury.International journal of medical sciences · 2022Review
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- Pharmacological restoration of anti-nociceptive functions in the prefrontal cortex relieves chronic pain.Progress in neurobiology · 2021Article
- Detecting acute pain signals from human EEG.Journal of neuroscience methods · 2021Article
- Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model.Molecular brain · 2020Article
- Emotional Mirror Neurons in the Rat's Anterior Cingulate Cortex.Current biology : CB · 2019Article
- Ensembles of change-point detectors: implications for real-time BMI applications.Journal of computational neuroscience · 2019Article
- Effects of Electroacupuncture on Pain Memory-Related Behaviors and Synchronous Neural Oscillations in the Rostral Anterior Cingulate Cortex in Freely Moving Rats.Neural plasticity · 2019Article
- Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
Pain is a complex sensory and affective experience. The current definition for pain relies on verbal reports in clinical settings and behavioral assays in animal models. These definitions can be subjective and do not take into consideration signals in the neural system. Local field potentials (LFPs) represent summed electrical currents from multiple neurons in a defined brain area. Although single neuronal spike activity has been shown to modulate the acute pain, it is not yet clear how ensemble activities in the form of LFPs can be used to decode the precise timing and intensity of pain. The anterior cingulate cortex (ACC) is known to play a role in the affective-aversive component of pain in human and animal studies. Few studies, however, have examined how neural activities in the ACC can be used to interpret or predict acute noxious inputs. Here, we recorded in vivo extracellular activity in the ACC from freely behaving rats after stimulus with non-noxious, low-intensity noxious, and high-intensity noxious stimuli, both in the absence and chronic pain. Using a supervised machine learning classifier with selected LFP features, we predicted the intensity and the onset of acute nociceptive signals with high degree of precision. These results suggest the potential to use LFPs to decode acute pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.