Evidence map›Paper›PMID 29844566›Full record

SynthesisNature communications2018

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Gail Davies, Max Lam, Sarah E Harris, Joey W Trampush, Michelle Luciano, W David Hill, Saskia P Hagenaars, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie and 212 more

Erratum issuedAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 395 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
395citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

395 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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335 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

222 authors.

Gail DaviesCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Max LamInstitute of Mental Health, Singapore, 539747, Singapore.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Joey W TrampushBrainWorkup, LLC, Los Angeles, 90033, CA, USA.ORCID http://orcid.org/0000-0003-0830-508X
Michelle LucianoCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-7306-3008
W David HillCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Saskia P HagenaarsCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Stuart J RitchieCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Chloe Fawns-RitchieCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
David C M LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-0544-7368
Judith A OkelyCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Ari V Ahola-OlliResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Catriona L K BarnesCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Lars BertramMax Planck Institute for Molecular Genetics, Berlin, 14195, Germany.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, Washington, USA.
Katherine E BurdickDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Andrea ChristoforouNORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Pamela DeRosseInstitute of Mental Health, Singapore, 539747, Singapore.
Srdjan DjurovicNORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo, 0373, Norway.ORCID http://orcid.org/0000-0001-9076-6365
Stella GiakoumakiDepartment of Psychology, University of Crete, Crete, GR-74100, Greece.
Sudheer GiddaluruNORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Daniel E GustavsonDepartment of Psychiatry, University of California, San Diego, 92093, CA, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-9405-9550
Edith HoferDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID http://orcid.org/0000-0002-8949-2587
Emma KnowlesDepartment of Psychiatry, Yale University School of Medicine, New Haven, 06511, CT, USA.
Jari LahtiDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.ORCID http://orcid.org/0000-0002-4310-5297
Markus LeberDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, D-50937, Germany.
Shuo LiDepartment of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Ingrid MelleNORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Derek MorrisNeuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, H91 TK33, Ireland.ORCID http://orcid.org/0000-0002-3413-570X
Christopher OldmeadowMedical Research Institute and Faculty of Health, University of Newcastle, New South Wa0les, 2308, Australia.
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Antony PaytonCentre for EpidemiologyDivision of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, M13 9PL, UK.
Raha PazokiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.
Katja PetrovicDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
Chandra A ReynoldsDepartment of Psychology, University of California Riverside, Riverside, 92521, CA, USA.
Muralidharan SargurupremrajUniversity of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, 04107, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-3575-5468
Albert V SmithIcelandic Heart Association, Kopavogur, IS-201, Iceland.
Natalie TerzikhanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Stella TrompetSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Sven J van der LeeDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.ORCID http://orcid.org/0000-0003-1606-8643
Erin B WareSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
B Gwen WindhamDepartment of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Jingyun YangRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, 60612, IL, USA.
Jin YuCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, 11030, NY, USA.ORCID http://orcid.org/0000-0002-2990-6602
David AmesNational Ageing Research Institute, Royal Melbourne Hospital, Victoria, 3052, Australia.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Philippe AmouyelUniv. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-LabEx DISTALZ, F-59000, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Ole A AndreassenDepartment of Psychology, University of Oslo, Oslo, 0373, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Nicola J ArmstrongMathematics and Statistics, Murdoch University, Perth, 6150, Australia.
Amelia A AssarehCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
John R AttiaHunter Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, 2305, Australia.ORCID http://orcid.org/0000-0001-9800-1308
Deborah AttixDepartment of NeurologyBryan Alzheimer's Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, 27708, NC, USA.
Dimitrios AvramopoulosDepartment of Psychiatry, Johns Hopkins University School of Medicine, MD, Baltimore, 21287, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, 60612, IL, USA.
Anne C BöhmerInstitute of Human Genetics, University of Bonn, Bonn, 53113, Germany.ORCID http://orcid.org/0000-0002-5716-786X
Patricia A BoyleRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, 60612, IL, USA.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Tyrone D CannonDepartment of Psychology, Yale University, New Haven, 06520, CT, USA.
Elizabeth T CirulliHuman Longevity Inc, Durham, 27709, NC, USA.
Eliza CongdonUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Emily Drabant Conley23andMe, Inc., Mountain View, 94041, CA, USA.
Janie CorleyCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Simon R CoxCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0003-4036-3642
Anders M DaleDepartment of Psychiatry, University of California, San Diego, 92093, CA, USA.
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.
Danielle DickDepartment of Psychology, Virginia Commonwealth University, Richmond, 23284, VA, USA.
Dwight DickinsonClinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, 20892, MD, USA.
Johan G ErikssonNational Institute for Health and Welfare, Helsinki, FI-00271, Finland.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.ORCID http://orcid.org/0000-0002-5488-2999
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Nelson A FreimerUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.ORCID http://orcid.org/0000-0003-3586-6587
He GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.
Ina GieglingDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298, VA, USA.
Scott D GordonQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, 21287, MD, USA.
Michael E GriswoldDepartment of Data Science, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, IS-201, Iceland.
Tamara B HarrisIntramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Annette M HartmannDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Alex HatzimanolisDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, 11528, Greece.
Gerardo HeissDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, 27599, NC, USA.
Elizabeth G HollidayHunter Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, 2305, Australia.
Peter K JoshiCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.ORCID http://orcid.org/0000-0002-6361-5059
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center, Tampere, FI-33014, Finland.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Ida KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Luca KleineidamDepartment of Psychiatry Medical Faculty, University of Cologne, Cologne, 50923, Germany.
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, 55905, MN, USA.
Nicole A KochanCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Bettina KonteDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.ORCID http://orcid.org/0000-0001-5287-308X
John B KwokBrain and Mind Centre-The University of Sydney, Camperdown, NSW, 2050, Australia.
Stephanie Le HellardNORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Teresa LeeCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Shu-Chen LiMax Planck Institute for Human Development, Berlin, 14195, Germany.
Christina M LillGenetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
Tian LiuMax Planck Institute for Molecular Genetics, Berlin, 14195, Germany.
Marisa KoiniDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
Edythe LondonUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Will T LongstrethDepartment of Neurology, School of Medicine, University of Washington, Seattle, 98195-6465, WA, USA.
Oscar L LopezDepartment of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, 15213, PA, USA.
Anu LoukolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Tobias LuckLIFE-Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.
Astri J LundervoldDepartment of Biological and Medical Psychology, University of Bergen, Bergen, 5009, Norway.ORCID http://orcid.org/0000-0002-6819-6164
Anders LundquistUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, SE-901 87, Sweden.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.ORCID http://orcid.org/0000-0002-4140-8139
Alison D MurrayGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0003-4915-4847
Anna C NeedDivision of Brain Sciences, Department of Medicine, Imperial College, London, SW7 2AZ, UK.ORCID http://orcid.org/0000-0003-3955-8207
Raymond NoordamSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Lars NybergUmeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, SE-901 87, Sweden.
William OllierCentre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, M13 9PT, UK.
Goran PapenbergMax Planck Institute for Human Development, Berlin, 14195, Germany.
Alison PattieDepartment of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Ozren PolasekGen-Info LLC, Zagreb, 10000, Croatia.
Russell A PoldrackDepartment of Psychology, Stanford University, Palo Alto, 94305-2130, CA, USA.ORCID http://orcid.org/0000-0001-6755-0259
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, Washington, USA.
Simone ReppermundCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, 04103, Germany.
Richard J RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405-7007, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Panos RoussosDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.
Suvi P RovioResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Yasaman SabaInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8036, Austria.
Fred W SabbRobert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, 97403, OR, USA.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Claudia L SatizabalDepartment of Neurology, Boston University School of Medicine, Boston, 02118, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Matthias SchmidDepartment of Medical Biometry, Informatics and Epidemiology, University Hospital, Bonn, D-53012, Germany.
Rodney J ScottHunter Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, 2305, Australia.
Matthew A ScultLaboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, 27708-0086, NC, USA.ORCID http://orcid.org/0000-0001-5554-8186
Jeannette SiminoDepartment of Data Science, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Nikolaos SmyrnisDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, 11528, Greece.
Aïcha SoumaréUniversity of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
Nikos C StefanisDepartment of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, 11528, Greece.
David J StottInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom.
Richard E StraubLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, 21205, MD, USA.
Kjetil SundetDepartment of Psychology, University of Oslo, Oslo, 0373, Norway.
Adele M TaylorDepartment of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.ORCID http://orcid.org/0000-0002-4275-9328
Christophe TzourioUniversity of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
André UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Aristotle N VoineskosCampbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, M5T 1L8, Canada.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Michael WagnerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, 53127, Germany.
Holger WagnerDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, 53127, Germany.
Leonie WeinholdDepartment of Medical Biometry, Informatics and Epidemiology, University Hospital, Bonn, D-53012, Germany.
K Hoyan WenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Elisabeth WidenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
Hieab H H AdamsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, 21287, USA.
Robert M BilderUCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, 90024, CA, USA.
Panos BitsiosDepartment of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, GR-71003, Greece.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Ornit Chiba-FalekDepartment of NeurologyBryan Alzheimer's Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, 27708, NC, USA.ORCID http://orcid.org/0000-0002-2529-8785
Aiden CorvinNeuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, DO2 AY89, Ireland.
Philip L De JagerCenter for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, 10032, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Stéphanie DebetteUniversity of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000, Bordeaux, France.
Gary DonohoeNeuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway, H91 TK33, Ireland.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK.ORCID http://orcid.org/0000-0002-7511-5684
Annette L FitzpatrickDepartment of Epidemiology, University of Washington, Seattle, 98195, WA, USA.
Michael GillNeuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, DO2 AY89, Ireland.ORCID http://orcid.org/0000-0003-0206-5337
David C GlahnDepartment of Psychiatry, Yale University School of Medicine, New Haven, 06511, CT, USA.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Narelle K HansellQueensland Brain Institute, University of Queensland, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0002-8229-9741
Ahmad R HaririLaboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, 27708-0086, NC, USA.
M Kamran IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Eero VuoksimaaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Matthew C KellerInstitute for Behavioral Genetics, University of Colorado, Boulder, 80309, CO, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, 92093, CA, USA.
Lenore LaunerIntramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, 20892, MD, USA.
Ulman LindenbergerMax Planck Institute for Human Development, Berlin, 14195, Germany.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FI-00014, Finland.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Neil PendletonDivision of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, and Manchester Medical School, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0003-0794-2386
David J PorteousCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Katri RäikkönenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Alfredo RamirezDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, D-50937, Germany.
Ivar ReinvangDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, 0315, Norway.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.ORCID http://orcid.org/0000-0001-6993-6884
Dan RujescuDepartment of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, 06108, Germany.
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, 8036, Austria.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8036, Austria.
Peter W SchofieldSchool of Medicine and Public Health, University of Newcastle, New South Wales, 2308, Australia.
Peter R SchofieldNeuroscience Research Australia, Sydney, 2031, Australia.ORCID http://orcid.org/0000-0003-2967-9662
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Vidar M SteenNORMENT, K.G. Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, 5021, Norway.
Julian N TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 2031, Australia.
Steven T TurnerDivision of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 55905, USA.
Cornelia M Van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015, The Netherlands.
Arno VillringerMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, 04103, Germany.
Daniel R WeinbergerLieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, 21205, MD, USA.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.
James F WilsonCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.ORCID http://orcid.org/0000-0001-5751-9178
Anil MalhotraCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, 11030, NY, USA.
Andrew M McIntoshCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-0198-4588
Catharine R GaleCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Sudha SeshadriRobert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, 97403, OR, USA.
Thomas H MosleyDepartment of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, 39216, MS, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, 77030, TX, USA.
Todd LenczCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, 11030, NY, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK. i.deary@ed.ac.uk.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Biotechnology and Biological Sciences Research Council BB/F019394/1Biotechnology and Biological Sciences Research Council BB/F022441/1Medical Research Council G0100594Medical Research Council G0400491Medical Research Council G0600237Medical Research Council G0901461Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/2Medical Research Council MC_UU_12011/4Medical Research Council MR/K026992/1Medical Research Council MR/R023484/1Medical Research Council MR/S015132/1NCATS NIH HHS UL1 TR001881NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG049789NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG055406NIA NIH HHS RF1 AG015819NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIGMS NIH HHS U54 GM115428NIMH NIH HHS L30 MH104879NIMH NIH HHS R01 MH085018NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10

Indexed as

AdolescentAdultAgedAged, 80 and overCognitionGenetic LociGenetic Predisposition to DiseaseHumansMental DisordersMiddle AgedMultifactorial InheritanceNeurodegenerative DiseasesNeurodevelopmental DisordersPolymorphism, Single NucleotideReaction TimeYoung Adult

Identifiers

PMID29844566
PMCPMC5974083

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