ArticleScientific reports2018
Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathways.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Single-cell genomics, metagenomics, and transcriptomics ofAquatic ecology · 2026Article
- Differential recruitment drives pathogen-mediated competition between species in an amphibian chytridiomycosis system.Ecological applications : a publication of the Ecological Society of America · 2025Article
- Batrachochytrium dendrobatidis strain affects transcriptomic response in liver but not skin in latitudinal populations of the common toad (Bufo bufo).Scientific reports · 2024Article
- Amphibian infection tolerance to chytridiomycosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- Ranavirus Amplification in Low-Diversity Amphibian Communities.Frontiers in veterinary science · 2022Article
- Exposure to a fungal pathogen increases the critical thermal minimum of two frog species.Ecology and evolution · 2021Article
- Immunological Aspects of Chytridiomycosis.Journal of fungi (Basel, Switzerland) · 2020Review
- Article
- Review of the Amphibian Immune Response to Chytridiomycosis, and Future Directions.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chytridiomycosis is among several recently emerged fungal diseases of wildlife that have caused decline or extinction of naïve populations. Despite recent advances in understanding pathogenesis, host response to infection remains poorly understood. Here we modelled a total of 162 metabolites across skin and liver tissues of 61 frogs from four populations (three long-exposed and one naïve to the fungus) of the Australian alpine tree frog (Litoria verreauxii alpina) throughout a longitudinal exposure experiment involving both infected and negative control individuals. We found that chytridiomycosis dramatically altered the organism-wide metabolism of clinically diseased frogs. Chytridiomycosis caused catastrophic failure of normal homeostatic mechanisms (interruption of biosynthetic and degradation metabolic pathways), and pronounced dysregulation of cellular energy metabolism. Key intermediates of the tricarboxylic acid cycle were markedly depleted, including in particular α-ketoglutarate and glutamate that together constitute a key nutrient pathway for immune processes. This study was the first to apply a non-targeted metabolomics approach to a fungal wildlife disease and specifically to dissect the host-pathogen interface of Bd-infected frogs. The patterns of metabolite accumulation we have identified reveal whole-body metabolic dysfunction induced by a fungal skin infection, and these findings have broad relevance for other fungal diseases.
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Registered trials
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