Evidence map›Paper›PMID 29844532›Full record

ArticleScientific reports2018

Optimization of Transcranial Direct Current Stimulation of Dorsolateral Prefrontal Cortex for Tinnitus: A Non-Linear Dose-Response Effect.

Giriraj Singh Shekhawat, Sven Vanneste

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Churning Better Transcranial Direct Current Stimulation Outcome with Accelerated Protocols: Understanding the Non-linear Dynamics through Metaplasticity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
  3. Tinnitus Rehabilitation Through Electrical Stimulation as a Neuromodulation Method: A Scoping Review.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Recent Updates on Tinnitus Management.Journal of audiology & otology · 2023
    Review
  10. Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023
    Review
  11. The Evaluation of Effects of Electrical Stimulation in Treatment of Patients with Chronic Tinnitus with Normal Hearing Sensitivity.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  12. Review
  13. Article
  14. Testing A Hypothesis: Tinnitus Control by Enhancing Physiological Inhibition.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Giriraj Singh ShekhawatSection of Audiology and Health Systems, University of Auckland, Auckland, New Zealand.
Sven VannesteLab for Clinical & Integrative Neuroscience, School of Behavioral and Brain Sciences, University of Texas, Dallas, USA. Sven.Vanneste@utdallas.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromodulation is defined as the process of augmenting neuroplasticity via invasive or non-invasive methods. Tinnitus is the perception of sound in the absence of its external source. The objective of this study was to optimize the parameters of transcranial direct current stimulation (tDCS) of dorsolateral prefrontal cortex (DLPFC) for tinnitus suppression. The following factors were optimized in the dose-response design (n = 111): current intensity (1.5 mA or 2 mA), stimulation duration (20 min or 30 min), and number of stimulation sessions (2, 4, 6, 8, or 10), with a 3-4 day washout period between each session. Participants underwent a minimum of 2 sessions in 1 week or maximum of 10 sessions in 5 weeks' time. Tinnitus loudness was measured in pre-post design using a 10-point numeric rating scale. There was a significant reduction in tinnitus loudness after tDCS of DLPFC. There was no significant difference between the intensity and duration of stimulation. As the number of sessions increased, there was a higher reduction in the tinnitus loudness; however, this effect plateaued after 6 sessions.

Indexed as

AdultAgedDose-Response Relationship, DrugFemaleHumansMaleMiddle AgedPrefrontal CortexRetrospective StudiesTinnitusTranscranial Direct Current Stimulation

Identifiers

PMID29844532
PMCPMC5974180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.