ArticleScientific reports2018
Hydrogen cyanide produced by the soil bacterium Chromobacterium sp. Panama contributes to mortality in Anopheles gambiae mosquito larvae.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- A broad-spectrum Chromobacterium biolarvicide formulation disrupts mosquito development through gut damage and apoptotic cell death and compromises vector competence.Communications biology · 2026Article
- Bioefficacy of Chromobacterium piscinae against the corn leafhopper Dalbulus maidis and genomic insights into virulence factors.Antonie van Leeuwenhoek · 2025Article
- Larval spongy moth transcriptomic response to ingestion of broad-versus narrow-spectrum insecticidal Chromobacterium species.Scientific reports · 2025Article
- A cytochromeApplied and environmental microbiology · 2025Article
- Increased environmental microbial diversity reduces the disease risk of a mosquitocidal pathogen.mBio · 2024Article
- Biotechnological Potential of Microorganisms for Mosquito Population Control and Reduction in Vector Competence.Insects · 2023Review
- Article
- Cross-species activation of hydrogen cyanide production by a promiscuous quorum-sensing receptor promotesMicrobiology (Reading, England) · 2023Article
- Discovery of novel natural products for mosquito control.Parasites & vectors · 2022Article
- Maize Apoplastic Fluid Bacteria Alter Feeding Characteristics of Herbivore (Microorganisms · 2022Article
- A Quorum Sensing-Regulated Type VI Secretion System Containing Multiple Nonredundant VgrG Proteins Is Required for Interbacterial Competition in Chromobacterium violaceum.Microbiology spectrum · 2022Article
- Contemporary exploitation of natural products for arthropod-borne pathogen transmission-blocking interventions.Parasites & vectors · 2022Review
- Larvicidal Activities againstTropical medicine and infectious disease · 2021Article
- Disrupting quorum sensing alters social interactions in Chromobacterium violaceum.NPJ biofilms and microbiomes · 2021Article
- A Blue-Purple Pigment-Producing Bacterium Isolated from the Vezelka River in the City of Belgorod.Microorganisms · 2021Article
- The Axenic and Gnotobiotic Mosquito: Emerging Models for Microbiome Host Interactions.Frontiers in microbiology · 2021Review
- Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies.Tropical medicine and infectious disease · 2020Review
- A Nonlive Preparation ofApplied and environmental microbiology · 2020Article
- Aedes aegypti vector competence studies: A review.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mosquito larvae continuously encounter microbes in their aquatic environment, which serve as food and play a critical role in successful development. In previous work, we isolated a Chromobacterium sp. (C.sp_P) with larvicidal activity from the midgut of dengue vector Aedes mosquitoes in Panama. In this study, we found a positive correlation between initial concentrations of C.sp_P and larval mortality rates, and that C.sp_P is more efficient at inducing larval mortality in a high nutrient environment. Multiple Chromobacterium species induce larval mortality with similar efficacy to C.sp_P except for C. subtsugae. We also found that a non-lethal dose of C.sp_P lengthens development time and increases mortality over multiple developmental stages, suggesting persistent effects of exposure. Additionally, we showed that larvicidal activity persists in the larval breeding water after removal of live bacteria, and that the larvicidal factor in C.sp_P-treated water is smaller than 3 kDa, heat resistant to 90 °C, and lost after vacuum centrifugation. We showed that C.sp_P produces hydrogen cyanide in culture and in larval water at concentrations sufficient to kill An. gambiae larvae, and treatment of the larval water with a cyanide antidote eliminated larvicidal activity. We conclude that a potential mechanism by which C.sp_P can induce larval mortality is via production of hydrogen cyanide.
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