ArticleScientific reports2018
Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach.Medical physics · 2025Article
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- Effect of Ultrahigh Dose Rate on Biomolecular Radiation Damage.Radiation research · 2024Article
- Toxicity assessment following conventional radiation therapy and pulsed low dose rate radiation therapy: an in vivo animal study.Radiation oncology (London, England) · 2024Article
- Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol.Scientific reports · 2024Article
- Zinc-Modified Titanate Nanotubes as Radiosensitizers for Glioblastoma: Enhancing Radiotherapy Efficacy and Monte Carlo Simulations.ACS omega · 2024Article
- The impact of dose rate on responses of human lens epithelial cells to ionizing irradiation.Scientific reports · 2024Article
- Dose Rate Effect on Cell Survival in BNCT.Current issues in molecular biology · 2023Article
- DNA‑PKcs phosphorylation specific inhibitor, NU7441, enhances the radiosensitivity of clinically relevant radioresistant oral squamous cell carcinoma cells.Biomedical reports · 2023Article
- Synthesis and characterization of actively HER-2 Targeted FeBioImpacts : BI · 2023Article
- Radiation dose rate effects: what is new and what is needed?Radiation and environmental biophysics · 2022Review
- Comparison of the Medical Uses and Cellular Effects of High and Low Linear Energy Transfer Radiation.Toxics · 2022Review
- Analysis of whole-blood antioxidant capacity after chronic and localized irradiation using the i-STrap method.Journal of radiation research · 2022Article
- Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability.Scientific reports · 2022Article
- Cryo-electron tomography related radiation-damage parameters for individual-molecule 3D structure determination.Frontiers in chemistry · 2022Review
- Comparison and Evaluation of Different Radiotherapy Techniques Using Biodosimetry Based on Cytogenetics.Cancers · 2021Article
- Chromosomal Location of Genes Differentially Expressed in Tumor Cells Surviving High-Dose X-ray Irradiation: A Preliminary Study on Radio-Fragile Sites.Current issues in molecular biology · 2021Article
- 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication.Scientific reports · 2021Article
- Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles.Scientific reports · 2021Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During exposure to ionizing radiation, sub-lethal damage repair (SLDR) competes with DNA damage induction in cultured cells. By virtue of SLDR, cell survival increases with decrease of dose-rate, so-called dose-rate effects (DREs). Here, we focused on a wide dose-rate range and investigated the change of cell-cycle distribution during X-ray protracted exposure and dose-response curves via hybrid analysis with a combination of in vitro experiments and mathematical modelling. In the course of flow-cytometric cell-cycle analysis and clonogenic assays, we found the following responses in CHO-K1 cells: (1) The fraction of cells in S phase gradually increases during 6 h exposure at 3.0 Gy/h, which leads to radio-resistance. (2) Slight cell accumulation in S and G
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